Vocalization development in common marmosets for neurodegenerative translational modeling
Vocalization development in common marmosets for neurodegenerative translational modeling
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DOI：
10.1080/01616412.2018.1438226
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发表时间：
2018-01-01
影响因子：
1.9
通讯作者：
Emborg, Marina E.
中科院分区：
文献类型：
--
作者：
Jones, Corinne A.;Duffy, Mary K.;Emborg, Marina E.
目的：为了促进在新兴的遗传常见的神经退行性疾病的绒猴模型发声的研究，我们的目的是分析呼叫类型的变化，在一个转化的研究环境中的年龄。我们假设，发声的声学参数会随着年龄的增长而变化，反映的发声器的增长和成熟的控制需要作出成人般的calls.Methods：19个发展中的普通绒猴纵向视频和音频记录的年龄在1-149天之间的自然设置没有任何发声诱导协议。对发声的呼叫类型（cry、tsik、trill、phee和trill-phee）进行编码，并对持续时间（sec）、最小和最大频率（Hz）和带宽（Hz）进行分析。混合模型线性回归进行评估的影响，年龄对呼叫参数上列出的每一个呼叫type.Results：随着年龄的增长，哭的持续时间（P = 0.038），最大频率（P = 0.047），和带宽（P = 0.023）。随着年龄的增长，Tsik呼叫的持续时间减少（P = 0.002），最小频率（P = 0.004）和最大频率（P = 0.005）增加。颤音呼叫的持续时间增加（P = 0.003），和trillphee带宽（P = 0.031）随着年龄的增长而下降。讨论：我们的研究结果表明，常见的绒猴发声的发展是呼叫类型依赖和声学参数的变化可以检测到没有复杂的发声启发范例或专门的录音设备。因此，我们证明了一个自然的协议，收集和客观地分析绒猴发声纵向的可行性。这种方法可能是有用的研究语音通信缺陷的遗传模型的神经退行性疾病。
Objectives: In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call-type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls.Methods: Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1-149 days in a naturalistic setting without any vocalization elicitation protocol. Vocalizations were coded for call type (cry, tsik, trill, phee, and trill-phee) and analyzed for duration (sec), minimum and maximum frequency (Hz), and bandwidth (Hz). Mixed model linear regressions were performed to assess the effects of age on call parameters listed above for each call type.Results: Cries decreased in duration (P = 0.038), maximum frequency (P = 0.047), and bandwidth (P = 0.023) with age. Tsik calls decreased in duration (P = 0.002) and increased in minimum frequency (P = 0.004) and maximum frequency (P = 0.005) with age. Trill calls increased in duration (P = 0.003), and trillphee bandwidth (P = 0.031) decreased with age.Discussion: Our results demonstrate that development of common marmoset vocalizations is call type dependent and that changes in acoustic parameters can be detected without complex vocalization elicitation paradigms or specialized audio recording equipment. Thus, we demonstrate the feasibility of a naturalistic protocol to collect and objectively analyze marmoset vocalizations longitudinally. This approach may be useful for studying vocal communication deficits in genetic models of neurodegenerative disorders.