THE SUPRACHIASMATIC NUCLEUS PARTICIPATES IN FOOD ENTRAINMENT: A LESION STUDY
THE SUPRACHIASMATIC NUCLEUS PARTICIPATES IN FOOD ENTRAINMENT: A LESION STUDY
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DOI：
10.1016/j.neuroscience.2009.11.061
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发表时间：
2010-02-17
期刊：
影响因子：
3.3
通讯作者：
Escobar, C.
中科院分区：
文献类型：
--
作者：
Angeles-Castellanos, M.;Salgado-Delgado, R.;Escobar, C.
日常进食安排包括几个大脑区域和外围的行为、新陈代谢、神经元活动和时钟基因表达的时间模式，而作为生物时钟的视交叉上核(SCN)仍然与光/暗周期相耦合。由于双侧SCN病变并不能消除食物缠绕的行为节律和激素节律，因此我们认为食物缠绕系统和轻度缠绕系统是相互独立的。特殊情况表明光和食物携带系统之间可能存在相互作用，并表明限制取食对SCN活性的调节。本研究探讨了SCN对食物携带节律的影响。对双侧颈总神经损毁(SCNX)大鼠的行为、核心温度、皮质酮和血糖的时间分布以及下丘脑和皮质边缘结构中Fos和PER1的免疫反应进行了研究。与正常对照组相比，SCNX大鼠的食物预期活性、食物携带温度和皮质酮升高表现得更早和更高。SCNX大鼠血糖水平在各时间点均较低，SCNX大鼠进食后下丘脑c-Fos阳性神经元增加，而皮质边缘结构c-Fos反应减弱。SCNX大鼠下丘脑结构PER1峰上调，下丘脑背内侧核(DMH)PER1峰上调，部分边缘结构PER1峰节律性减弱。这些结果表明，SCN在食物夹带过程中积极参与调节下丘脑和皮质边缘结构的反应，从而导致预期反应的增加。(C)2010年IBRO。爱思唯尔有限公司出版。保留所有权利。
Daily feeding schedules entrain temporal patterns of behavior, metabolism, neuronal activity and clock gene expression in several brain areas and periphery while the suprachiasmatic nucleus (SCN), the biological clock, remains coupled to the light/dark cycle. Because bilateral lesions of the SCN do not abolish food entrained behavioral and hormonal rhythms it is suggested that food entrained and light entrained systems are independent of each other. Special circumstances indicate a possible interaction between the light and the food entrained systems and indicate modulation of SCN activity by restricted feeding. This study explores the influence of the SCN on food entrained rhythms. Food entrained temporal profiles of behavior, core temperature, corticosterone and glucose, as well as Fos and PER1 immunoreactivity in the hypothalamus and corticolimbic structures were explored in rats bearing bilateral SCN lesions (SCNX). In SCNX rats food anticipatory activity and the food entrained temperature and corticosterone increase were expressed with earlier onset and higher values than in intact controls. Glucose levels were lower in SCNX rats in all time points and SCNX rats anticipation to a meal induced higher c-Fos positive neurons in the hypothalamus, while a decreased c-Fos response was observed in corticolimbic structures. SCNX rats also exhibited an upregulation of the PER1 peak in hypothalamic structures, especially in the dorsomedial hypothalamic nucleus (DMH), while in some limbic structures PERI rhythmicity was dampened. The present results indicate that the SCN participates actively during food entrainment modulating the response of hypothalamic and corticolimbic structures, resulting in an increased anticipatory response. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.