Pathway of transient electronics towards connected biomedical applications
Pathway of transient electronics towards connected biomedical applications
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瞬态电子学走向互联生物医学应用的途径
DOI：
10.1039/d2nr06068j
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发表时间：
2023
期刊：
影响因子：
6.7
通讯作者：
Cheng, Huanyu
中科院分区：
文献类型：
--
作者：
Dutta, Ankan;Cheng, Huanyu
瞬态电子器件自问世以来在硬件安全和具有诊断治疗能力的医疗植入物中显示出有前途的应用。对装置瞬态的控制允许装置在其功能操作之后“随意溶解”，从而导致按需瞬态电子器件的发展。这篇综述讨论了触发策略的最新发展和优点（例如，电的、热的、超声的和光的），用于控制按需瞬态电子器件的退化。我们还总结了生物可吸收传感器的医疗诊断，包括在电生理学和神经化学传感的代表性应用。沿着医疗诊断的深刻进步，也讨论了用于生物医学或医疗植入体社区的治疗系统的开始，例如电刺激和药物递送。然而，在真实的医疗保健基础设施中实现瞬态电子系统仍处于起步阶段。许多关键的挑战仍然需要解决，包括解耦多模态传感信号的策略，在多种刺激存在下的溶解选择性，以及完整的传感-刺激闭环系统。因此，审查讨论了未来的机会，在瞬态去耦传感器和强大的瞬态设备，这是选择一个特定的刺激，并作为基于硬件的密码。还分析了闭环触发器启用电子设备的最新进展，以便在全闭环瞬态系统中使用数据驱动的人工智能驱动控制器。
Transient electronic devices have shown promising applications in hardware security and medical implants with diagnosing therapeutics capabilities since their inception. Control of the device transience allows the device to “dissolve at will” after its functional operation, leading to the development of on-demand transient electronics. This review discusses the recent developments and advantages of triggering strategies (e.g., electrical, thermal, ultrasound, and optical) for controlling the degradation of on-demand transient electronics. We also summarize bioresorbable sensors for medical diagnoses, including representative applications in electrophysiology and neurochemical sensing. Along with the profound advancements in medical diagnosis, the commencement of therapeutic systems such as electrical stimulation and drug delivery for the biomedical or medical implant community has also been discussed. However, implementing a transient electronic system in real healthcare infrastructure is still in its infancy. Many critical challenges still need to be addressed, including strategies to decouple multimodal sensing signals, dissolution selectivity in the presence of multiple stimuli, and a complete sensing–stimulation closed-loop system. Therefore, the review discusses future opportunities in transient decoupling sensors and robust transient devices, which are selective to a particular stimulus and act as hardware-based passwords. Recent advancements in closed-loop controller-enabled electronics have also been analyzed for future opportunities of using data-driven artificial intelligence-powered controllers in fully closed-loop transient systems.