Cigarette smoking is correlated with the periventricular hyperintensity grade on brain magnetic resonance imaging
Cigarette smoking is correlated with the periventricular hyperintensity grade on brain magnetic resonance imaging
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DOI：
10.1161/01.str.27.4.645
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发表时间：
1996-04-01
期刊：
影响因子：
8.3
通讯作者：
Kitani, M
中科院分区：
文献类型：
--
作者：
Fukuda, H;Kitani, M
背景和目的一些研究发现吸烟或脂质异常与脑t -2加权磁共振成像（MRI）扫描的心室周围高强度（PVHs）呈显著负相关，这是令人惊讶的，因为吸烟和高脂血症被认为是脑血管疾病的危险因素。我们在t -2加权mri上研究了吸烟与脂质异常和PVHs的关系。方法对253例40岁以上患者进行MRI扫描，并采用5分制对PVHs进行回顾性评估。排除正在接受高脂血症药物治疗的患者。血清总胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯水平在空腹状态下通过自动酶促程序测定。采用弗里德瓦尔德方程计算低密度脂蛋白（LDL）胆固醇水平。年龄、性别、高血压状况、抗高血压治疗、是否有糖尿病和中风史都包括在分析中。结果多元线性回归分析显示，年龄、高血压、吸烟、抗高血压治疗与PVH评分有显著独立相关。标准偏回归系数为。39 （P150 mg/dL）、性别、糖尿病、卒中史与PVH评分无关。结论吸烟是PVH评分的一个微弱但显著的正预测因子，与年龄、高血压和抗高血压治疗无关。脂质异常与PVH评分无关。
Background and Purpose A few studies have observed a significant inverse correlation between cigarette smoking or lipid abnormalities and periventricular hyperintensities (PVHs) on T-2-weighted magnetic resonance imaging (MRI) scans of the brain, which is surprising because smoking and hyperlipidemia are considered risk factors for cerebrovascular disease. We investigated the relation between smoking and lipid abnormalities and PVHs on T-2-weighted MRIs.Methods MRI scans were performed in 253 patients over the age of 40 years, and PVHs were assessed retrospectively by use of a five-point scale. Patients who were receiving medical treatment for hyperlipidemia were excluded. Serum levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides were determined in the fasting state by an automated enzymatic procedure. The low-density lipoprotein (LDL) cholesterol level was calculated by use of Friedewald's equation. Age, sex, hypertensive status, antihypertensive treatment, presence or absence of diabetes mellitus: and history of stroke were included in the analysis.Results Multiple linear regression analysis showed that age: hypertension, smoking, and antihypertensive treatment were significantly and independently correlated with the PVH score. The standard partial regression coefficients were .39 (P150 mg/dL), sex, diabetes mellitus, and a history of stroke were not correlated with the PVH score.Conclusions Cigarette smoking was a weak but significant positive predictor of the PVH score and was independent of age, hypertension, and antihypertensive treatment. Lipid abnormalities were not related to the PVH score.