The history and enduring contributions of planarians to the study of animal regeneration.
The history and enduring contributions of planarians to the study of animal regeneration.
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DOI：
10.1002/wdev.82
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发表时间：
2013-05
影响因子：
--
通讯作者：
Alvarado, Alejandro Sanchez
中科院分区：
文献类型：
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作者：
Elliott, Sarah A.;Alvarado, Alejandro Sanchez
由于具有几乎无限的再生因衰老和损伤而失去的组织的能力，真涡虫长期以来一直吸引着博物学家。仅在西半球，他们有记载的历史就跨越了200多年。在世纪早期，Planarians被描述为“刀口下的不朽”，对这些非凡动物的初步研究受到其他生物再生研究的显著影响，以及19世纪末和20世纪初蓬勃发展的实验胚胎学领域。本文试图将涡虫再生的研究置于一个更广阔的历史背景下，通过关注这一领域的知识的意义和演变。它还综合了我们目前对涡虫再生机制的分子理解，这些机制是从这种动物相对较近的进入分子遗传时代以来发现的。
Having an almost unlimited capacity to regenerate tissues lost to age and injury, planarians have long fascinated naturalists. In the Western hemisphere alone, their documented history spans more than 200 years. Planarians were described in the early 19th century as being “immortal under the edge of the knife,” and initial investigation of these remarkable animals was significantly influenced by studies of regeneration in other organisms and from the flourishing field of experimental embryology in the late 19th and early 20th centuries. This review strives to place the study of planarian regeneration into a broader historical context by focusing on the significance and evolution of knowledge in this field. It also synthesizes our current molecular understanding of the mechanisms of planarian regeneration uncovered since this animal’s relatively recent entrance into the molecular-genetic age.