TrackFly: Virtual reality for a behavioral system analysis in free-flying fruit flies
TrackFly: Virtual reality for a behavioral system analysis in free-flying fruit flies
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DOI：
10.1016/j.jneumeth.2008.02.016
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发表时间：
2008-06-15
影响因子：
3
通讯作者：
Dickinson, Michael H.
中科院分区：
文献类型：
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作者：
Fry, Steven N.;Rohrseitz, Nicola;Dickinson, Michael H.
现代神经科学和对仿生控制设计的兴趣需要越来越复杂的实验技术，这些技术可以应用于现实行为条件下自由移动的动物。为了探索自由飞行的果蝇（果蝇）的感觉运动飞行控制机制，我们为风洞配备了基于标准数字硬件和 3D 路径跟踪系统的虚拟现实 (VR) 显示系统。我们通过“单参数开环”测试范例的例子展示了这种方法的实验能力。它提供了（1）开环视觉刺激下瞬态反应的直接测量； (2)过程自动化带来的高数据吞吐量和标准化测量条件； (3) 由于明确的测试条件而简化了数据分析。基于标准硬件和软件技术，我们的方法为自由移动动物的广泛行为应用提供了经济实惠、易于复制和通用的解决方案。先进行为研究工具的特别相关性源于对用于疾病研究的转基因生物和动物模型进行详细行为分析的需要。 (c) 2008 Elsevier B.V. 保留所有权利。
Modern neuroscience and the interest in biomimetic control design demand increasingly sophisticated experimental techniques that can be applied in freely moving animals under realistic behavioral conditions. To explore sensorimotor flightcontrol mechanisms in free-flying fruit flies (Drosophila melanogaster), we equipped a wind tunnel with a Virtual Reality (VR) display system based on standard digital hardware and a 3D path tracking system. We demonstrate the experimental power of this approach by example of a 'one-parameter open loop' testing paradigm. It provided (1) a straightforward measure of transient responses in presence of open loop visual stimulation; (2) high data throughput and standardized measurement conditions from process automation; and(3) simplified data analysis due to well-defined testing conditions.Being based on standard hardware and software techniques, our methods provide an affordable, easy to replicate and general solution for a broad range of behavioral applications in freely moving animals. Particular relevance for advanced behavioral research tools originates from the need to perform detailed behavioral analyses in genetically modified organisms and animal models for disease research. (c) 2008 Elsevier B.V. All rights reserved.