BETA-AMYLOID PROTEIN DEPOSITION IN THE BRAIN AFTER SEVERE HEAD-INJURY - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMERS-DISEASE
BETA-AMYLOID PROTEIN DEPOSITION IN THE BRAIN AFTER SEVERE HEAD-INJURY - IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMERS-DISEASE
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DOI：
10.1136/jnnp.57.4.419
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发表时间：
1994-04-01
影响因子：
11
通讯作者：
GRAHAM, DI
中科院分区：
文献类型：
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作者：
ROBERTS, GW;GENTLEMAN, SM;GRAHAM, DI
在最近的一项初步研究中，据报道，严重的头部损伤导致β淀粉样蛋白（β AP）沉积在30%存活不到两周的患者的皮质带中。现在已经检查了152名患者（年龄范围为8周-81岁）的多个皮层区域，这些患者在严重头部损伤后的生存时间在4小时到2.5年之间。该系列与一组44名神经正常对照（年龄范围51至80岁）进行了比较。用β AP抗体进行免疫染色证实了最初的发现，即30%的头部损伤病例在一个或多个皮质区域有β AP沉积。年龄的增加似乎加重了β AP沉积的程度，并且还研究了与头部损伤相关的其他病理变化的潜在相关性。此外，β淀粉样前体蛋白（β APP）的免疫反应性增加，在周围的β AP存款的神经元胞体。这项研究的数据支持的建议，β APP的表达增加是一个急性期的一部分，在人类大脑中的神经元损伤，β APP的广泛过度表达可以导致沉积β AP和启动阿尔茨海默病型过程中的几天内，头部损伤可能是一个重要的病因因素在阿尔茨海默病。
In a recent preliminary study it was reported that a severe head injury resulted in the deposition of beta amyloid protein (beta AP) in the cortical ribbon of 30% of patients who survived for less than two weeks. Multiple cortical areas have now been examined from 152 patients (age range 8 weeks-81 years) after a severe head injury with a survival time of between four hours and 2.5 years. This series was compared with a group of 44 neurologically normal controls (age range 51 to 80 years). Immunostaining with an antibody to beta AP confirmed the original findings that 30% of cases of head injury have beta AP deposits in one or more cortical areas. Increasing age seemed to accentuate the extent of beta AP deposition and potential correlations with other pathological changes associated with head injury were also investigated. In addition, beta amyloid precursor protein (beta APP) immunoreactivity was increased in the perikarya of neurons in the vicinity of beta AP deposits. The data from this study support proposals that increased expression of beta APP is part of an acute phase response to neuronal injury in the human brain, that extensive overexpression of beta APP can lead to deposition of beta AP and the initiation of an Alzheimer disease-type process within days, and that head injury may be an important aetiological factor in Alzheimer's disease.