Flavour identification in frontotemporal lobar degeneration
Flavour identification in frontotemporal lobar degeneration
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DOI：
10.1136/jnnp-2012-303853
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发表时间：
2013-01-01
影响因子：
11
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Omar, Rohani;Mahoney, Colin J.;Warren, Jason D.
背景：风味加工缺陷可能在额颞叶变性（FTLD）中具有重要的临床意义。目的探讨食用菌的风味加工过程。方法对25例FTLD患者（12例为行为变异性额颞叶痴呆（bvFTD）， 8例为语义变异性原发性进行性失语症（svPPA）， 5例为非流利变异性原发性进行性失语症（nfvPPA））和17例健康对照者)进行前瞻性风味识别研究，采用一种基于味觉与文字和图片跨模态匹配的新测试方法。所有受试者都完成了一般的神经心理学评估，并使用改进的宾夕法尼亚大学气味识别测试评估气味识别。使用基于体素的形态计量学分析患者队列的脑MRI体积，以确定风味识别的区域灰质关联。结果bvFTD和svPPA亚组与健康对照组比较，差异均有统计学意义（p < 0.05）
Background Deficits of flavour processing may be clinically important in frontotemporal lobar degeneration (FTLD).Objective To examine flavour processing in FTLD.Methods We studied flavour identification prospectively in 25 patients with FTLD (12 with behavioural variant frontotemporal dementia (bvFTD), eight with semantic variant primary progressive aphasia (svPPA), five with non-fluent variant primary progressive aphasia (nfvPPA)) and 17 healthy control subjects, using a new test based on cross-modal matching of flavours to words and pictures. All subjects completed a general neuropsychological assessment, and odour identification was also assessed using a modified University of Pennsylvania Smell Identification Test. Brain MRI volumes from the patient cohort were analysed using voxel-based morphometry to identify regional grey matter associations of flavour identification.Results Relative to the healthy control group, the bvFTD and svPPA subgroups showed significant (p