Duality in the Th17-Treg developmental decision.
Duality in the Th17-Treg developmental decision.
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DOI：
10.3410/b1-5
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发表时间：
2009-01-21
期刊：
影响因子：
--
通讯作者：
Weaver CT
中科院分区：
文献类型：
--
作者：
Hatton RD;Weaver CT
每种效应CD4 t细胞谱系——Th1、Th2和最近发现的Th17——都起源于多能性naïve前体，其发育命运主要由与抗原信号协同作用的细胞因子控制。值得注意的是，Th17谱系的发展与调节性T细胞的发展有关，调节性T细胞通过对细胞因子转化生长因子- β的共同需求，消除或下调Th17反应以保持免疫稳态。一些新的研究为这些亚群的前体被定向到不同谱系的机制提供了见解。
Each of the effector CD4 T-cell lineages - Th1, Th2, and the more recently identified Th17 - arises from pluripotent naïve precursors whose developmental fate is largely controlled by cytokines that act in concert with antigenic signals. Remarkably, development of the Th17 lineage has been linked to that of regulatory T cells, which obviate or downregulate Th17 responses to preserve immune homeostasis, through a shared requirement for the cytokine transforming growth factor-beta. Several new studies offer insights into the mechanism whereby the precursors of these subsets are directed into distinct lineages.