Extraneous Tissue A Potential Source for Diagnostic Error in Surgical Pathology
Extraneous Tissue A Potential Source for Diagnostic Error in Surgical Pathology
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DOI：
10.1309/ajcp4ffsbphau8iu
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发表时间：
2011-11-01
影响因子：
3.5
通讯作者：
Anderson, Gina M.
中科院分区：
文献类型：
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作者：
Layfield, Lester J.;Witt, Benjamin L.;Anderson, Gina M.
“飞蚊症”是诊断错误的潜在原因，可能在组织处理和载玻片制备过程中出现。我们的目标是确定幻灯片中飞蚊症的频率以及对其识别有用的特征。我们审查了载玻片中飞蚊症的质量保证 (QA) 记录，并前瞻性检查了另外 1,000 张载玻片中的飞蚊症，并记录了 1 个或多个切片中的飞蚊症大小、位置和存在情况。在 QA 审查的 521,661 张载玻片中，检测到 65 个飞蚊症：28 个存在于组织块中，37 个仅在单个水平中发现。在 1,000 张前瞻性检查的载玻片中，检测到 12 个飞蚊症； 9 个仅出现在单个切片中。飞蚊症是诊断错误的潜在来源，出现在 0.01% 至 1.2% 的载玻片中。从水浴中拾取漂浮物似乎是最常见的（接近 60%）。仅 1 级的飞蚊症以及与样本组织类型不匹配是飞蚊症的无关性质的线索。
"Floaters" represent a potential cause of diagnostic error and may arise during tissue processing and slide preparation. Our objective was to determine the frequency of floaters in slides and features useful in their recognition. We reviewed quality assurance (QA) records for floaters in slides and prospectively examined 1,000 additional slides for floaters and documented floater size, location, and presence in 1 or more sections.In the 521,661 slides reviewed for QA, 65 floaters were detected: 28 were present in the tissue block, and 37 were found only in a single level. In the 1,000 prospectively examined slides, 12 floaters were detected; 9 were only in a single section.Floaters represent a potential source of diagnostic error and occur in 0.01% to 1.2% of slides. Pick up of floaters from the water bath appears most common (similar to 60%). Floaters in only 1 level and mismatch with the specimen tissue type are clues to the extraneous nature of the floater.