Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease.
Circadian Rhythm Neuropeptides in Drosophila: Signals for Normal Circadian Function and Circadian Neurodegenerative Disease.
复制标题
果蝇的昼夜节律神经肽：正常昼夜节律功能和昼夜节律神经退行性疾病的信号
DOI：
10.3390/ijms18040886
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发表时间：
2017-04-21
影响因子：
5.6
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
He Q;Wu B;Price JL;Zhao Z
从原核生物到真核生物，昼夜节律是一种普遍存在的现象。四十多年来，人们对昼夜节律的内在和外源性调节进行了研究。本文综述了果蝇的核心内源性振荡，重点介绍了介导其输出和整合的神经肽、神经递质和激素，以及其中几种（色素分散因子（PDF）和胰岛素样肽）与神经退行性疾病的关系。这些信号分子为正常的昼夜节律功能传递重要的网络连接和信号信息，但PDF和胰岛素样肽也可以在携带昼夜节律突变或处于衰老状态的果蝇中传递导致细胞凋亡、神经变性增强和认知能力下降的信号。
Circadian rhythm is a ubiquitous phenomenon in many organisms ranging from prokaryotes to eukaryotes. During more than four decades, the intrinsic and exogenous regulations of circadian rhythm have been studied. This review summarizes the core endogenous oscillation in Drosophila and then focuses on the neuropeptides, neurotransmitters and hormones that mediate its outputs and integration in Drosophila and the links between several of these (pigment dispersing factor (PDF) and insulin-like peptides) and neurodegenerative disease. These signaling molecules convey important network connectivity and signaling information for normal circadian function, but PDF and insulin-like peptides can also convey signals that lead to apoptosis, enhanced neurodegeneration and cognitive decline in flies carrying circadian mutations or in a senescent state.