Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases
Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases
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DOI：
10.1016/j.preteyeres.2014.05.002
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发表时间：
2014-09-01
影响因子：
17.8
通讯作者：
Papavassiliou, Athanasios G.
中科院分区：
文献类型：
--
作者：
Kandarakis, Stylianos A.;Piperi, Christina;Papavassiliou, Athanasios G.
晚期糖基化终末产物（AGEs）与黄斑变性、白内障形成、糖尿病视网膜病变和青光眼相关的视力丧失有关，其致病性主要是由于AGEs在眼组织中的蓄积，介导细胞外基质蛋白的异常交联和内皮连接复合物的破坏，从而影响细胞的通透性，介导血管生成和血视网膜屏障的破坏。此外，AGEs通过干扰ATP的产生、增强氧化应激以及调节抗血管生成和抗炎基因的基因表达来严重影响细胞代谢。阐明AGE在不同眼区室中诱导的作用机制将有助于理解与眼部疾病相关的复杂细胞和分子过程。几种具有抗糖化和抗氧化特性的药剂以及AGE交联“破坏剂”目前已被应用于眼部疾病。饮食的作用和某些营养保健品的有益效果为管理影响数百万人生活质量的慢性视觉障碍提供了另一种方法。(C)2014爱思唯尔有限公司版权所有。
Advanced glycation end products (AGEs) have been implicated in vision loss associated with macula degeneration, cataract formation, diabetic retinopathy and glaucoma.This pathogenic potential is mainly attributed to their accumulation in ocular tissues where they mediate aberrant crosslinking of extracellular matrix proteins and disruption of endothelial junctional complexes that affects cell permeability, mediates angiogenesis and breakdown of the inner blood-retinal barrier. Furthermore, AGEs severely affect cellular metabolism by disrupting ATP production, enhancing oxidative stress and modulating gene expression of anti-angiogenic and anti-inflammatory genes. Elucidation of AGE-induced mechanisms of action in different eye compartments will help in the understanding of the complex cellular and molecular processes associated with eye diseases. Several pharmaceutical agents with anti-glycating and anti-oxidant properties as well as AGE crosslink 'breakers' have been currently applied to eye diseases. The role of diet and the beneficial effects of certain nutriceuticals provide an alternative way to manage chronic visual disorders that affect the quality of life of millions of people. (C) 2014 Elsevier Ltd. All rights reserved.