Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans.
Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans.
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DOI：
10.1017/s0007114520002044
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发表时间：
2020-11-14
期刊：
影响因子：
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通讯作者：
Burdge GC
中科院分区：
文献类型：
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作者：
West AL;Miles EA;Lillycrop KA;Han L;Napier JA;Calder PC;Burdge GC
EPA和DHA是正常细胞功能所必需的，也可以带来健康益处。鱼油是人类消费的EPA和DHA的主要来源。然而，食物选择和对海洋鱼类资源可持续性的担忧限制了EPA + DHA摄入量的饮食建议的有效性。含有EPA + DHA的转基因植物的种子油是EPA和DHA的潜在替代来源。本研究调查了含有EPA和DHA的转基因亚麻荠籽油（CSO）在盲法交叉研究中作为膳食补充剂食用时，在增加EPA和DHA浓度方面是否与鱼油（FO）一样有效。健康男性和女性（n 31;年龄53（范围20-74）岁）随机摄入450 mg/d EPA + DHA，以CSO或FO形式提供，持续8周，随后进行6周洗脱，然后转换为食用其他试验油。在每个补充期开始和结束时采集空腹静脉血样。食用试验油显著（P <0.05）增加了血浆TAG、磷脂酰胆碱和胆固醇酯中EPA和DHA的浓度。在EPA和DHA的增量方面，试验油之间没有显著差异。在红细胞EPA + DHA比例的增加方面，试验油之间没有显著差异（CSO，12%; P <0.0001和FO，8%; P = 0.02）。总之，这些发现表明，食用CSO与FO一样有效，可以增加人体中EPA和DHA的浓度。
EPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA + DHA intakes. Seed oils from transgenic plants that contain EPA + DHA are a potential alternative source of EPA and DHA. The present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in increasing EPA and DHA concentrations when consumed as a dietary supplement in a blinded crossover study. Healthy men and women (n 31; age 53 (range 20–74) years) were randomised to consume 450 mg/d EPA + DHA provided either as either CSO or FO for 8 weeks, followed by 6 weeks washout and then switched to consuming the other test oil. Fasting venous blood samples were collected at the start and end of each supplementation period. Consuming the test oils significantly (P < 0·05) increased EPA and DHA concentrations in plasma TAG, phosphatidylcholine and cholesteryl esters. There were no significant differences between test oils in the increments of EPA and DHA. There was no significant difference between test oils in the increase in the proportion of erythrocyte EPA + DHA (CSO, 12 %; P < 0·0001 and FO, 8 %; P = 0·02). Together, these findings show that consuming CSO is as effective as FO for increasing EPA and DHA concentrations in humans.