Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
复制标题
大鼠中枢黑皮质素系统的激活会持续减少身体和脂肪量，而与热量减少无关。
DOI：
10.1139/cjpp-2017-0440
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发表时间：
2018
影响因子：
2.1
通讯作者：
Scarpace,PhilipJ
中科院分区：
文献类型：
--
作者：
Côté,Isabelle;Green,SaraM;Morgan,Drake;Carter,ChristyS;Tümer,Nihal;Scarpace,PhilipJ
最近的证据表明，melanotan II (MTII) 可以减少体重，而与热量减少无关。由于 MTII 会引起短暂的吞咽不足，因此热量减少仍然被认为是 MTII 介导的体重减轻的主要机制。为了检查热量减少对 MTII 响应的长期体重损失的影响，我们在随意喂养的动物（MTII 和对照）中集中注射 MTII 或媒介物，并与与 MTII 组配对喂养（PF）的一组动物进行比较。每天记录食物摄入量和体重，每两周评估一次身体成分。本研究表明，中枢 MTII 介导的体重减轻仅部分由热量限制介导，并且长期体重减轻与最初的吞咽不足无关。更重要的是，中央 MTII 给药诱导快速但持续的脂肪量减少，与热量减少无关。在整个研究过程中，MTII 处理的动物保持了瘦肉/脂肪质量比，而 PF 动物的瘦肉/脂肪质量比短暂降低，只有当食物摄入量恢复到对照水平时，该比例才恢复正常。总之，可以得出结论，大鼠中枢黑皮质素系统的激活会持续减少身体和脂肪量，而与热量减少无关。
Recent evidence indicate that melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group. Food intake and body mass were recorded daily, and body composition was assessed biweekly. The present study demonstrates that central MTII-mediated body mass loss is only partially mediated by caloric restriction, and the long-term body mass loss is independent of the initial hypophagia. More importantly, central MTII administration induced a rapid but sustained fat mass loss, independently of caloric reduction. MTII-treated animals preserved their lean/fat mass ratio throughout the study, whereas PF animals underwent a transient reduction of lean/fat mass ratio that was only normalized when food intake returned to Control level. In summary, it can be concluded that activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.