Stimulus-dependent γ (30-50 Hz) oscillations in simple and complex fast rhythmic bursting cells in primary visual cortex
Stimulus-dependent γ (30-50 Hz) oscillations in simple and complex fast rhythmic bursting cells in primary visual cortex
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DOI：
10.1523/jneurosci.0374-05.2005
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发表时间：
2005-06-01
影响因子：
5.3
通讯作者：
Contreras, D
中科院分区：
文献类型：
--
作者：
Cardin, JA;Palmer, LA;Contreras, D
振荡活动由许多神经系统产生。丘脑和皮层中的γ波段（类似于40 Hz）振荡自发地发生并响应于感觉刺激。快速节律爆发（FRB）细胞（也称为震颤细胞）包括一类独特的皮层神经元，在通过电流注入去极化期间，固有地产生高频动作电位的爆发，爆发间频率在30和50 Hz之间。在本研究中，我们首次表明，FRB细胞在初级视觉皮层可以是简单的或复杂的，并分布在所有的皮层层。引人注目的是，简单和复杂的FRB细胞产生尖峰脉冲在伽马频率响应去极化电流脉冲，但只有简单的FRB细胞表现出选择性的，刺激功能依赖性增加伽马振荡响应视觉刺激。此外，我们发现，超极化不降低视觉诱发的γ振荡的相对功率的V-M响应的FRB细胞。因此，我们的研究结果表明，视觉诱发的γ活动在个人简单和复杂的FRB细胞产生的节律性突触输入，而不是由去极化依赖激活的内在属性在很大程度上。最后，FRB细胞在第6层的存在表明皮质丘脑反馈的作用，在增强丘脑振荡和促进产生的corticothalamocortical振荡回路。我们提出，而不是作为起搏器，FRB细胞放大和分布刺激驱动的伽马振荡在新皮层。
Oscillatory activity is generated by many neural systems. gamma band (similar to 40 Hz) oscillations in the thalamus and cortex occur spontaneously and in response to sensory stimuli. Fast rhythmic bursting (FRB) cells ( also called chattering cells) comprise a unique class of cortical neurons that, during depolarization by current injection, intrinsically generate bursts of high-frequency action potentials with an interburst frequency between 30 and 50 Hz. In the present study, we show for the first time that FRB cells in the primary visual cortex can be either simple or complex and are distributed throughout all cortical layers. Strikingly, both simple and complex FRB cells generate spike bursts at gamma frequencies in response to depolarizing current pulses, but only simple FRB cells exhibit a selective, stimulus feature-dependent increase in gamma oscillations in response to visual stimulation. In addition, we find that hyperpolarization does not reduce the relative power of visually evoked gamma oscillations in the V-m response of FRB cells. Our results thus indicate that visually evoked gamma activity in individual simple and complex FRB cells is generated in large part by rhythmic synaptic input, rather than by depolarization-dependent activation of intrinsic properties. Finally, the presence of FRB cells in layer 6 suggests a role for corticothalamic feedback in potentiating thalamic oscillations and facilitating the generation of a corticothalamocortical oscillatory loop. We propose that rather than functioning as pacemakers, FRB cells amplify and distribute stimulus-driven gamma oscillations in the neocortex.