Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term
Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term
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DOI：
10.1016/j.ejogrb.2005.03.006
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发表时间：
2005-11-01
影响因子：
2.6
通讯作者：
Garfield, RE
中科院分区：
文献类型：
--
作者：
Fittkow, CT;Maul, H;Garfield, RE
目的：探讨前列腺素局部应用于足月引产后宫颈光诱导荧光(LIF)的变化及其与Bishop-Score评分的相关性。研究设计：对41例前列腺素足月引产孕妇使用特制的胶原镜测量宫颈表面光诱导荧光(LIF)。分别于用药前和用药后4h进行LIF和Bishop评分。采用配对学生t检验、Wilcoxon符号等级检验、线性回归、Spearman相关和Fisher精确检验。结果：应用前列腺素治疗后，宫颈LIF显著降低(治疗前为0.982士0.04，治疗后为0.885士0.037，p=0.025)。LIF的下降与应用PG前的LIF呈正相关(r=0.61)。41例患者Bishop评分均有不同程度提高。结论：宫颈应用前列腺素可降低LIF测量的交联胶原蛋白的含量。这种影响只在先前有高交联型胶原的患者中观察到。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score.Study design: The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4 h after the administration of prostaglandin. Paired Student's t-test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate.Results: Cervical LIF decreased significantly after prostaglandin application (0.982 +/- 0.04 [before] to 0.885 +/- 0.037 [after], p = 0.025). The decrease in LIF correlated with the initial LIF before PG-application (r = 0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score.Conclusions: Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen. (C) 2005 Elsevier Ireland Ltd. All rights reserved.