Live Imaging of Early Developmental Processes in Mammalian Embryos with Optical Coherence Tomography.
Live Imaging of Early Developmental Processes in Mammalian Embryos with Optical Coherence Tomography.
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DOI：
10.1142/s1793545809000619
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Dickinson ME
中科院分区：
文献类型：
--
作者：
Larin KV;Larina IV;Liebling M;Dickinson ME
哺乳动物模型心血管发育的早期胚胎成像需要一种能够以高空间和时间分辨率穿透和区分许多组织层的方法。在本文中，我们评估了光学相干断层扫描（OCT）技术在发育过程中不同阶段（从7.5 dpc到10.5 dpc）的小鼠胚胎结构三维成像的能力。所获得的结果表明，所收集的数据适用于定量和定性测量，以评估小鼠模型的心血管功能，这可能会扩大我们对胚胎心脏及其发育成成人心脏的复杂性的认识。
Early embryonic imaging of cardiovascular development in mammalian models requires a method that can penetrate through and distinguish the many tissue layers with high spatial and temporal resolution. In this paper we evaluate the capability of Optical Coherence Tomography (OCT) technique for structural 3D embryonic imaging in mouse embryos at different stages of the developmental process ranging from 7.5 dpc up to 10.5 dpc. Obtained results suggest that the collected data is suitable for quantitative and qualitative measurements to assess cardiovascular function in mouse models, which is likely to expand our knowledge of the complexity of the embryonic heart, and its development into an adult heart.