5-Diacetoxymethyl-cycloSal-d4TMP -: A prototype of enzymatically activated cycloSal-pronucleotides
5-Diacetoxymethyl-cycloSal-d4TMP -: A prototype of enzymatically activated cycloSal-pronucleotides
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DOI：
10.1080/15257770701504025
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发表时间：
2007-01-01
影响因子：
1.3
通讯作者：
Meier, C.
中科院分区：
文献类型：
--
作者：
Gisch, N.;Balzarini, J.;Meier, C.
合成了一类新的“锁定”修饰的环Sal-pronucleotides。以5-二乙酰氧基甲基-cycloSal-d4 T-单磷酸（5-di-AM-cycloSal-d4 TMP）为例，阐明了酶促活化的cycloSal-原核苷酸的概念。合成，水解研究，并对艾滋病毒的抗病毒活性。
A new class of "lock-in" modified cyclo Sal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cycloSal-d4T-monophosphate (5-di-AM-cycloSal-d4TMP), the concept of enzymatically activated cycloSal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.