A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients
A novel NR3C2 polymorphism and the increased thyroid-stimulating hormone concentration are associated with venlafaxine treatment outcome in Chinese Han MDD patients
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一种新的 NR3C2 多态性和促甲状腺激素浓度升高与中国汉族 MDD 患者的文拉法辛治疗结果相关
DOI：
10.1016/j.psychres.2019.112690
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发表时间：
2019-11
影响因子：
11.3
通讯作者：
He Guang
中科院分区：
文献类型：
--
作者：
Yuan Fan;Yuan Ruixue;Ren Decheng;Bi Yan;Niu Weibo;Guo Zhenming;Wu Xi;Xu Fei;Sun Qianqian;Ma Gaini;Yang Fengping;Zhu Yuhao;Yu Tao;Li Xingwang;He Lin;Shi Lei;He Guang
目的：本研究旨在探讨文拉法辛抗抑郁疗效与NR 3C 2基因多态性及治疗过程中两种神经内分泌激素变化的关系。方法：195例汉族抑郁症患者接受文拉法辛治疗6周。分别于治疗开始和结束时测定促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）水平。选择6个单核苷酸多态性（SNPs）（NR 3C 2：rs 1512325、rs 1512342、rs 2070951; NR 3C 1：rs6191、rs6196、rs 10482614）进行高通量SNP基因分型。比较缓解组和非缓解组的等位基因和基因型频率。结果如下：结果发现，缓解组与非缓解组间NR 3C 2基因rs 1512325位点基因型频率差异有统计学意义（P< 0.05）。缓解组rs 1512325 C等位基因频率显著低于对照组（P< 0.05）。缓解组治疗后TSH水平明显升高（P< 0.05）。结论：中国汉族MDD患者NR 3C 2基因rs 1512325位点和TSH水平可能与文拉法辛治疗效果有关。
Objective: We aimed to study the association among venlafaxine antidepressive outcome,NR3C2gene polymorphisms and the change of two neuroendocrine hormones during treatment. Methods: 195 Chinese Han major depressive disorder (MDD) patients were recruited and received a 6-week venlafaxine treatment in this study. Adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH) levels were measured at the beginning and at the end of treatment. Six single-nucleotide polymorphisms (SNPs) (NR3C2: rs1512325, rs1512342, rs2070951;NR3C1: rs6191, rs6196, rs10482614) were selected for high-throughput SNP genotyping. Allele and genotype frequencies of them were compared between remission and non-remission groups. Results: We found that genotype frequency of the rs1512325 located in theNR3C2gene was significantly different between remission and non-remission groups respectively (p< 0.05). Meanwhile, the frequency of the rs1512325 C-allele was significantly lower (p< 0.05) in remission group. The TSH concentration significantly increased after venlafaxine treatment in remission group (p< 0.05). Conclusion: The rs1512325 inNR3C2gene and TSH concentration may be related to venlafaxine treatment outcome in Chinese Han MDD patients.
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影响因子：
3.7
作者：
Lopez-Duran, Nestor L.;Kovacs, Maria;George, Charles J.
通讯作者：
George, Charles J.
影响因子：
3.6
作者：
Lee S;Jeong J;Kwak Y;Park SK
通讯作者：
Park SK
影响因子：
3.5
作者：
Rawal, Rajesh;Teumer, Alexander;Homuth, Georg
通讯作者：
Homuth, Georg
影响因子：
4.4
作者：
G. Réus;R. Stringari;K. F. Ribeiro;A. Cipriano;B. Panizzutti;L. Stertz;C. Lersch;F. Kapczinski
通讯作者：
G. Réus;R. Stringari;K. F. Ribeiro;A. Cipriano;B. Panizzutti;L. Stertz;C. Lersch;F. Kapczinski
DOI：
10.1176/appi.ps.201400480
发表时间：
2015-12-01
期刊：
Psychiatric services (Washington, D.C.)
影响因子：
--
作者：
Hall CA;Simon KM;Lenze EJ;Dew MA;Begley A;Butters MA;Blumberger DM;Stack JA;Mulsant B;Reynolds CF 3rd
通讯作者：
Reynolds CF 3rd