A COMPARISON OF THE REGIONAL CIRCULATION IN THE FEET BETWEEN DIALYSIS AND NON-DIALYSIS PATIENTS USING INDOCYANINE GREEN ANGIOGRAPHY
A COMPARISON OF THE REGIONAL CIRCULATION IN THE FEET BETWEEN DIALYSIS AND NON-DIALYSIS PATIENTS USING INDOCYANINE GREEN ANGIOGRAPHY
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DOI：
10.1177/1457496916666412
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发表时间：
2017-09-01
影响因子：
2.4
通讯作者：
Uetake, H.
中科院分区：
文献类型：
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作者：
Nishizawa, M.;Igari, K.;Uetake, H.
背景和目的：与非透析病例相比，外周动脉疾病的透析病例更容易出现严重肢体缺血，下肢大截肢率明显较高。在透析严重肢体缺血病例中，病变分布在更远端。本研究的目的是探讨吲哚菁绿血管造影在确定透析患者与非透析患者足部区域循环差异方面的有效性。 材料与方法：研究对象包括 62 例，其中透析患者 20 例，非透析患者 42 例。我们比较了透析组和非透析组感兴趣区域的吲哚菁绿血管造影参数，包括从吲哚菁绿开始到最大强度的强度大小（Imax）、从吲哚菁绿开始到最大强度的时间（Tmax）、从荧光开始到最大强度一半的时间（T1/2）以及从最大强度到下降到最大强度的90%的时间（Td90%）。这些吲哚菁绿血管造影参数在感兴趣区域 1（Chopart 关节）、感兴趣区域 2（Lisfranc 关节）和感兴趣区域 3（第一跖骨远端区域）进行测量。结果：在透析组和非透析组之间的比较中，观察到 Tmax、T1/2 和 Td90% 存在显着差异，特别是在感兴趣区域 3。结论：在本研究中，我们表明区域与使用吲哚菁绿血管造影的非透析患者相比，透析患者的组织灌注更加恶化。 Tmax、T1/2 和 Td90% 可能是有用的临床参数，用于比较透析患者和非透析患者下肢缺血的严重程度。
Background and Aims: Peripheral artery disease in dialysis cases is more prone to critical limb ischemia compared to non-dialysis cases, with a significantly high rate of major amputation of the lower limbs. Lesions are distributed on the more distal side in dialysis critical limb ischemia cases. The aim of this study was to investigate the usefulness of indocyanine green angiography to determine differences in the regional circulation in the foot between dialysis and non-dialysis patients.Materials and Methods: The subjects included 62 cases, among which 20 were dialysis patients and 42 were non-dialysis patients. We compared the indocyanine green angiography parameters for regions of interest in the dialysis and non-dialysis groups, which included the magnitude of intensity from indocyanine green onset to maximum intensity (Imax), the time from indocyanine green onset to maximum intensity (Tmax), the time elapsed from the fluorescence onset to half the maximum intensity (T1/2), and the time from maximum intensity to declining to 90% of the maximum intensity (Td90%). These indocyanine green angiography parameters were measured at region of interest 1 (the Chopart joint), region of interest 2 (the Lisfranc joint), and region of interest 3 (the distal region of the first metatarsal bone).Results: In the comparison between the dialysis and non-dialysis groups, a significant difference was observed regarding Tmax, T1/2, and Td90%, especially in region of interest 3.Conclusion: In this study, we show that regional tissue perfusion is more deteriorated in dialysis patients compared with non-dialysis patients using indocyanine green angiography. Tmax, T1/2, and Td90% could be useful clinical parameters to compare ischemic severity of the lower limb between dialysis and non-dialysis patients.