Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery
Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery
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DOI：
10.1002/bjs.6375
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发表时间：
2008-11-01
影响因子：
9.6
通讯作者：
Bonnet, F.
中科院分区：
文献类型：
--
作者：
Marret, E.;Rolin, M.;Bonnet, F.
背景资料：利多卡因的连续静脉给药可能会减少肠梗阻和疼痛的持续时间腹部surgery.Methods：三个数据库（Medline，Embase和科克伦对照试验注册）检索随机对照试验比较连续静脉利多卡因输注期间和腹部手术后与安慰剂。根据随机化、双盲和随访，使用牛津质量评分对研究设计进行评分。结果指标为肠梗阻持续时间、住院时间、术后疼痛和恶心呕吐发生率。共161例患者接受静脉注射利多卡因，159名对照。静脉注射利多卡因可缩短肠梗阻持续时间（加权平均差（WMD）-8-36 h; P < 0.001），住院时间（WMD -0.84天; P = 0.002），术后24小时的疼痛强度（0-100 mm视觉模拟量表）结论：利多卡因在腹部手术中和术后持续静脉给药可改善患者的康复，缩短住院时间。
Background: Continuous intravenous administration of lidocaine may decrease the duration of ileus and pain after abdominal surgery.Methods: Three databases (Medline, Embase and the Cochrane Controlled Trials Register) were searched to retrieve randomized controlled trials comparing continuous intravenous lidocaine infusion during and after abdominal surgery with placebo. Study design was scored using the Oxford Quality Score based on randomization, double-blinding and follow-up. Outcome measures were duration of ileus, length of hospital stay, postoperative pain, and incidence of nausea and vomiting.Results: Eight trials were selected. A total of 161 patients received, intravenous lidocaine, with 159 controls. Intravenous lidocaine administration decreased the duration of ileus (weighted mean difference (WMD) -8-36 h; P < 0.001), length of hospital stay (WMD -0.84 days; P = 0.002), postoperative pain intensity at 24 h after operation on a 0-100-mm visual analogue scale (WMD -5.93 mm; P = 0.002), and the incidence of nausea and vomiting (odds ratio 0.39; P = 0.006).Conclusion: Continuous intravenous administration of lidocaine during and after abdominal surgery improves patient rehabilitation and shortens hospital stay.