Effects of loading orientation on the morphology of the predicted yielded regions in trabecular bone.
Effects of loading orientation on the morphology of the predicted yielded regions in trabecular bone.
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DOI：
10.1007/s10439-008-9619-4
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发表时间：
2009-02
影响因子：
3.8
通讯作者：
Niebur, Glen L.
中科院分区：
文献类型：
--
作者：
Shi, Xiutao;Wang, Xiang;Niebur, Glen L.
虽然骨质疏松骨的骨密度和结构的影响已被广泛研究，屈服和失败的微观力学很少受到关注。然而，理解与失败相关的结构特征应该为评估骨质量提供见解。在这项研究中，微观结构有限元模型被用来计算在十个牛胫骨骨小梁样本的组织水平屈服的区域。在两种加载条件下，对四种表观菌株的屈服区域的形态、数量和平均体积进行定量。对于轴向载荷，由于压缩应变而屈服的组织的平均纵横比随着表观应变的增加而增加，沿着主要小梁方向扩展。这表明，当样本在轴上加载时，组织水平屈服沿沿着垂直小梁进展。的数量，但不是体积，由于拉伸应变产生的区域随着施加载荷的增加而增加，与松弛和屈服区域周围的应力重新分布一致。当试样垂直于主轴压缩时，屈服区的纵横比接近1，而屈服区的数量、平均体积和平均厚度增加。这表明在组织水平上发生的局部高应变与支柱的弯曲一致，而不是轴向变形。总的来说，这些结果为骨小梁衰竭提供了新的见解，这与评估骨折风险的诊断测试或评估骨质疏松症的治疗有关。
While the effects of bone mineral density and architecture in osteoporotic bone have been studied extensively, the micromechanics of yielding and failure have received less attention. However, understanding architectural features associated with failure should provide insight into assessing bone quality. In this study, microstructural finite element models were used to compute regions of tissue level yielding in ten bovine tibial trabecular bone samples. The morphology, number, and mean volume of the yielded regions were quantified for four apparent strains under two loading conditions. For on-axis loading, the mean aspect ratio of the tissue that yielded due to compressive strain increased with increasing apparent strain, expanding along the principal trabecular orientation. This suggests that tissue level yielding progresses along vertical trabeculae when a specimen is loaded on-axis. The number, but not the volume, of the regions yielded due to tensile strain increased with increasing applied load, consistent with relaxation and redistribution of stresses around the yielded regions. When the specimens were compressed perpendicular to the principal axis, the aspect ratio of the yielded regions was close to one, while the number, mean volume, and mean thickness of the yielded regions increased. This indicates that localized high strains consistent with bending rather than axial deformation of struts occur at the tissue level. Overall, the results provide new insight into trabecular bone failure, which is relevant to assessing diagnostic tests for fracture risk or evaluating osteoporosis treatments.
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影响因子：
2.4
作者：
GIBSON, LJ
通讯作者：
GIBSON, LJ
DOI：
10.1115/1.2798314
发表时间：
1998-04-01
影响因子：
1.7
作者：
Guldberg, RE;Hollister, SJ;Charras, GT
通讯作者：
Charras, GT
DOI：
10.1115/1.2800865
发表时间：
1999-12-01
影响因子：
1.7
作者：
Niebur, GL;Yuen, JC;Keaveny, TM
通讯作者：
Keaveny, TM
影响因子：
3.9
作者：
COWIN, SC
通讯作者：
COWIN, SC
影响因子：
2.4
作者：
Gibson, LJ
通讯作者：
Gibson, LJ