Ultrafast Z-Spectroscopy for 129Xe NMR-Based Sensors
Ultrafast Z-Spectroscopy for 129Xe NMR-Based Sensors
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DOI：
10.1021/jz402261h
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发表时间：
2013-12-05
影响因子：
5.7
通讯作者：
Berthault, Patrick
中科院分区：
文献类型：
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作者：
Boutin, Celine;Leonce, Estelle;Berthault, Patrick
当与超极化物质一起工作时，通常难以在连续实验中保持稳定的磁化水平，这使得它们在痕量水平上的检测繁琐，即使与化学交换饱和转移（CEST）结合也是如此。我们在此报告使用超快Z-光谱作为一种强大的手段来检测低浓度的基于NMR的传感器，并测量进出氙交换。原始序列的修改使多个传感器的多路检测，以及在一个单一的拍摄方式的交换建立速率常数的提取。
When working with hyperpolarized species, it is often difficult to maintain a stable level of magnetization over consecutive experiments, which renders their detection at the trace level cumbersome, even when combined with chemical exchange saturation transfer (CEST). We report herein the use of ultrafast Z-spectroscopy as a powerful means to detect low concentrations of Xe-129 NMR-based sensors and to measure the in out xenon exchange. Modifications of the original sequence enable a multiplexed detection of several sensors, as well as the extraction of the exchange buildup rate constant in a single-shot fashion.