Engineered nanomaterials for synergistic photo-immunotherapy
Engineered nanomaterials for synergistic photo-immunotherapy
复制标题
DOI：
10.1016/j.biomaterials.2022.121425
复制
发表时间：
2022-02-22
期刊：
影响因子：
14
通讯作者：
Zhang, Peng
中科院分区：
文献类型：
--
作者：
Guo, Ranran;Wang, Siqi;Zhang, Peng
纳米材料协同的光动力疗法（PDT）和光热疗法（PTT）作为有效和非侵入性的治疗方式，在对抗不同类型的癌症方面显示出显著的优势。然而，由于肿瘤的远处转移和复发，PTT和PDT都不能完全根除肿瘤。最近，光免疫疗法引起了极大的关注，因为已经报道了光疗法通过触发免疫原性细胞死亡（ICD）参与免疫治疗，导致肿瘤特异性抗原（TSA）和损伤相关分子模式（DAMP）的分泌。特别是，新兴的兴趣偏向于操纵纳米材料形成独特的药物递送系统，这是光疗和免疫疗法的组合所必需的，通过促进树突状细胞（DC）的成熟和细胞毒性T淋巴细胞（CTL）的浸润来消除转移性肿瘤细胞。本文综述了近年来工程纳米材料增强协同光免疫治疗抗癌效果的最新策略，重点介绍了其激活抗肿瘤免疫反应、逆转肿瘤免疫抑制微环境（TIME）、调节免疫抑制细胞与肿瘤细胞之间的相互作用、促进免疫细胞浸润以及提高光免疫治疗诱导的ICD效率等方面的研究进展。目前的挑战和未来的机会，在工程纳米材料，以调节协同光免疫疗法进行了讨论。
Nanomaterial-synergized photodynamic therapy (PDT) and photothermal therapy (PTT), as efficient and noninvasive treatment modalities, have shown significant advantages in fighting different types of cancer. However, neither PTT nor PDT can completely eradicate tumors due to distant metastasis and recurrence of tumors. Recently, photo-immunotherapy have attracted great attention as phototherapy has been reported to participate in immunotherapy by triggering immunogenic cell death (ICD), resulting in the secretion of tumor specific antigen (TSAs) and damage-associated molecular patterns (DAMPs). In particular, emerging interests are biased towards manipulating nanomaterials to form unique drug delivery systems, which are necessary for the combination of phototherapy and immunotherapy to eliminate metastatic tumor cells by promoting the maturation of dendritic cells (DCs) and the infiltration of cytotoxic T lymphocytes (CTLs). This review elaborates on the latest strategies on engineering nanomaterials to enhance the anti-cancer efficiency of synergistic photoimmunotherapy, with emphasis on the activation of anti-tumor immune response, the reversal of tumor immunosuppressive microenvironment (TIME), the regulation of the interaction between immunosuppressive cells and tumor cells, the infiltration of immune cells and improved efficiency of photo-immunotherapy-induced ICD. Current challenges and future opportunities in engineering nanomaterials to modulate synergistic photoimmunotherapy are also discussed.