New frontiers for mass spectrometry based upon structures for lossless ion manipulations.
New frontiers for mass spectrometry based upon structures for lossless ion manipulations.
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DOI：
10.1039/c7an00031f
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发表时间：
2017-03-27
期刊：
影响因子：
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通讯作者：
Smith RD
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文献类型：
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作者：
Ibrahim YM;Hamid AM;Deng L;Garimella SV;Webb IK;Baker ES;Smith RD
无损离子操纵结构（SLIM）为高效、复杂和扩展的气相离子操纵提供了一种新的范例。SLIM是通过将DC和RF电势施加到在两个平行表面上图案化的电极阵列而产生的电场来创建的。电场提供无损的离子操作，包括有效的离子传输和存储。SLIM模块已经开发使用恒定和振荡电场（例如行波）两者来影响离子运动。迄今为止，SLIM的离子操作包括：扩展捕获、离子选择、离子解离和离子迁移谱（IMS）分离，实现了前所未有的超高分辨率。因此，SLIM为以前不切实际的操作提供了基础，例如离子多次穿过蛇形路径的非常长的路径长度离子迁移率分离，以及基于离子迁移率分离和其他离子分布的时间和空间压缩来扩展这些开发的效用的新能力。SLIM设备的发展在过去的三年中进行了审查，我们提供了各种离子操纵的例子，并简要讨论了潜在的应用和新的方向。SLIM利用离子导管中的操作，离子导管由通过向在两个平面表面上图案化的电极阵列施加电势而产生的电场创建
Structures for lossless ion manipulations (SLIM) provide a new paradigm for efficient, complex and extended gas phase ion manipulations. SLIM are created from electric fields generated by the application of DC and RF potentials to arrays of electrodes patterned on two parallel surfaces. The electric fields provide lossless ion manipulations, including effective ion transport and storage. SLIM modules have been developed using both constant and oscillatory electric fields (e.g. traveling waves) to affect the ion motion. Ion manipulations demonstrated to date with SLIM include: extended trapping, ion selection, ion dissociation, and ion mobility spectrometry (IMS) separations achieving unprecedented ultra high resolution. SLIM thus provide the basis for previously impractical manipulations, such as very long path length ion mobility separations where ions traverse a serpentine path multiple times, as well as new capabilities that extend the utility of these developments based on temporal and spatial compression of ion mobility separations and other ion distributions. The evolution of SLIM devices developed over the last three years is reviewed and we provide examples of various ion manipulations performed, and briefly discuss potential applications and new directions. SLIM utilize manipulations in ion conduits created with electric fields generated by applying potentials to arrays of electrodes patterned on two planar surfaces