Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes
Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes
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Cu(I) 催化重氮烷与末端炔偶联对映选择性合成三取代丙二烯
DOI：
10.1021/jacs.6b09674
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发表时间：
2016-11-09
影响因子：
15
通讯作者：
Wang, Jianbo
中科院分区：
文献类型：
--
作者：
Chu, Wen-Dao;Zhang, Lei;Wang, Jianbo
通过Cu（I）催化的芳基重氮烷和末端炔与手性双恶唑啉配体的交叉偶联反应，实现了对映选择性合成三取代联烯。Cu（I）卡宾的炔基迁移插入被认为是构建轴向手性的关键步骤。
A highly enantioselective synthesis of trisubstituted allenes has been achieved through Cu(I)-catalyzed cross-coupling of aryldiazoalkanes and terminal alkynes with chiral bisoxazoline ligands. Alkynyl migratory insertion of Cu(I) carbene is proposed as the key step for the construction of axial chirality.