Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors: An initial experience
Additional value of dual-energy CT to differentiate between benign and malignant mediastinal tumors: An initial experience
复制标题
DOI：
10.1016/j.ejrad.2013.05.040
复制
发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Choi, Byoung Wook
中科院分区：
文献类型：
--
作者：
Lee, Seung Hyun;Hur, Jin;Choi, Byoung Wook
目的：探讨双能计算机断层扫描（DECT）区分恶性和良性纵膈肿瘤的可行性。材料和方法：我们前瞻性招募了25名患者（14名男性;平均年龄：56.7岁），这些患者在胸部X线检查或非对比胸部计算机断层扫描（CT）中疑似纵膈肿瘤。所有患者均接受了使用宝石光谱成像（GSI）模式（GE HD 750）的两相DECT。对于定量分析，两名研究者测量了早期和延迟相肿瘤的以下参数：以Hounsfield单位（HU）为单位的CT衰减值和碘浓度（mg/ml）。病理结果用于最终诊断。统计分析采用Fisher精确检验和Mann-Whitney t检验。结果：10例（40%）良性病变，而15例（60%）恶性病变。良性肿瘤与恶性肿瘤的碘浓度测量值在早期均存在显著性差异（1.38 mg/ml vs. 2.41 mg/ml，p = 0.001）和延迟期（1.52 mg/ml vs. 2.84 mg/ml，p = 0.001），而两个阶段的平均衰减值无显著差异（分别为57.8 HU vs. 69.1 HU，p = 0.067和67.4 HU vs. 78.4 HU，p = 0.086）。结论：采用定量分析方法的双能量CT可用于区分良性和恶性纵隔肿瘤（C）2013 Elsevier爱尔兰有限公司。保留所有权利。
Objectives: To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors.Materials and methods: We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test.Results: 10 patients (40%) had benign pathology, while 15(60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p = 0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p = 0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p = 0.067 and 67.4 HU vs. 78.4 HU, p = 0.086, respectively).Conclusions: Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors (C) 2013 Elsevier Ireland Ltd. All rights reserved.