PPARD May Play a Protective Role against the Development of Schizophrenia
PPARD May Play a Protective Role against the Development of Schizophrenia
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DOI：
10.1155/2020/3480412
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发表时间：
2020-08-07
期刊：
影响因子：
2.9
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Li, Xinrong;Liu, Sha;Xu, Yong
PPARD已被认为有助于精神分裂症（SCZ）的病因，其潜在机制在很大程度上未知。在这里，我们首先收集并分析了三组PPARD表达谱：（1）18名健康对照（HC）受试者，（2）14名临床高危（CHD）患者，和（3）19名早发SCZ（EOS）患者。在此基础上，我们进行了系统的通路分析，探讨PPARD影响SCZ病理发展的可能机制。与HC组相比，EOS组中PPARD的表达略微降低（LFC=-0.34;p=0.23），而EOS组中PPARD的表达增加（LFC=0.65;p=0.20）。然而，EOS组和EOS组之间存在显著差异（LFC=-0.99;p=0.015），反映了SCZ发作前后PPARD表达的变化量。通路分析表明PPARD过表达可能通过调节10种蛋白或分子抑制SCZ的病理发展，包括8种SCZ启动子的失活和2种SCZ抑制剂的激活。我们的研究结果支持PPARD和SCZ之间的关联。所确定的途径可能有助于了解PPARD导致SCZ病因的潜在机制。
PPARD has been suggested to contribute to the etiology of schizophrenia (SCZ) with the underlying mechanisms largely unknown. Here, we first collected and analyzed the PPARD expression profile from three groups: (1) 18 healthy control (HC) subjects, (2) 14 clinical high-risk (CHR) patients, and (3) 19 early onset of SCZ (EOS) patients. After that, we conducted a systematical pathway analysis to explore the potential mechanisms involved in PPARD exerting influence on the pathological development of SCZ. Compared to the HC group, the expression of PPARD was slightly decreased in the EOS group (LFC=-0.34;p=0.23) and increased in the CHR group (LFC=0.65;p=0.20). However, there was a significant difference between the EOS group and the CHR group (LFC=-0.99;p=0.015), reflecting the amount of variation in PPARD expression before and after the onset of SCZ. Pathway analysis suggested that overexpression of PPARD may regulate ten proteins or molecules to inhibit the pathological development of SCZ, including the deactivation of eight SCZ promoters and stimulation of two SCZ inhibitors. Our results support the association between PPARD and SCZ. The pathways identified may help in the understanding of the potential mechanisms by which PPARD contributes to the etiology of SCZ.