A dietary pattern protective against type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC) -: Potsdam Study cohort
A dietary pattern protective against type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC) -: Potsdam Study cohort
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DOI：
10.1007/s00125-005-1743-1
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发表时间：
2005-06-01
期刊：
影响因子：
8.2
通讯作者：
Boeing, H
中科院分区：
文献类型：
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作者：
Heidemann, C;Hoffmann, K;Boeing, H
本研究的目的是确定与糖尿病相关生物标志物相关的饮食模式，并调查这种模式是否与2型糖尿病的发病率相关。对192例新发2型糖尿病患者和382例年龄和性别相匹配的对照者进行了巢式病例对照研究。所有受试者均参与了基于人群的欧洲癌症与营养前瞻性研究（EPIC）-波茨坦研究。在降秩回归中，使用48种食物组的摄入数据作为暴露变量，生物标志物HbA（1）c、HDL胆固醇、C反应蛋白和脂联素作为响应变量，得出饮食模式评分。通过条件Logistic回归分析评估评分与糖尿病风险的相关性。高评分的饮食模式的特点是新鲜水果的摄入量高，高热量的软饮料，啤酒，红肉，家禽，加工肉类，豆类和面包（不包括全麦面包）的摄入量低。高分受试者的血浆HDL胆固醇和脂联素浓度较高，而HbA 1 c和C反应蛋白浓度较低。多变量校正后，饮食模式评分增加五分位数的2型糖尿病的比值比分别为1.0、0.59、0.51、0.26和0.27（趋势p=0.0006）。所鉴定的饮食模式的高分与更有利的生物标志物谱和2型糖尿病的发病率大幅降低相关。
The aim of this study was to identify a dietary pattern associated with diabetes-related biomarkers and to investigate whether this pattern is associated with the incidence of type 2 diabetes. A nested case-control study of 192 cases of incident type 2 diabetes and 382 control subjects matched for sex and age was conducted. All subjects were participants in the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Dietary pattern score was derived using intake data on 48 food groups as exposure variables and the biomarkers HbA(1)c, HDL cholesterol, C-reactive protein and adiponectin as response variables in reduced rank regression. The association of the score with diabetes risk was estimated by conditional logistic regression analysis. A high score for the identified dietary pattern was characterised by a high intake of fresh fruit and a low intake of high-caloric soft drinks, beer, red meat, poultry, processed meat, legumes and bread (excluding wholegrain bread). Subjects with high scores had high plasma concentrations of HDL cholesterol and adiponectin and low plasma concentrations of HbA(1)c and C-reactive protein. After multivariate adjustment, the odds ratios for type 2 diabetes across increasing quintiles of the dietary pattern score were 1.0, 0.59, 0.51, 0.26 and 0.27, respectively (p=0.0006 for trend). A high score for the identified dietary pattern is associated with a more favourable biomarker profile and a substantially reduced incidence of type 2 diabetes.