Positron emission tomography in primary brain tumours using cobalt-55
Positron emission tomography in primary brain tumours using cobalt-55
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DOI：
10.1097/00006231-199708000-00007
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发表时间：
1997-08-01
影响因子：
1.5
通讯作者：
Korf, J
中科院分区：
文献类型：
--
作者：
Jansen, HM;Dierckx, RA;Korf, J
原发性脑肿瘤通常通过计算机断层扫描（CT）和磁共振成像（MRI）进行评估，有时与正电子发射断层扫描（PET）结合使用。我们使用钴-55（Co-55）作为钙（Ga）示踪剂来可视化腐烂的肿瘤组织，这是基于钙流入在细胞死亡和白细胞活化中都是必不可少的这一事实。净钴-55摄取可能是细胞衰变，白细胞浸润，（再）灌注和钴-55的药理学特征的结果。3例原发性恶性脑肿瘤患者（首次就诊）在静脉注射0.5 mCi Co-55后进行了CT、MRI和Go-PET研究。组织学诊断通过活检或切除获得。Go-PET显示了每一个脑肿瘤，并显示出与CT和MRI良好的地形一致性。Go-PET提供了关于坏死核心的部位和大小以及腐烂肿瘤的坏死周围边缘的更多详细信息。钴-55吸收指数在2.6和5.3之间变化。钴-55表现出在腐烂的组织中的吸收，无论血脑屏障的完整性如何。坏死或存活的肿瘤组织均未显示出对Co-55的亲和力。由于Co-55是很容易适用于PET和单光子发射断层扫描（SPET），在摄取机制和功能意义的Co-55示踪剂的差异进行了讨论，在Tl-201 SPET。我们提出了一个（有限的）试点系列的三名患者提出的要求，这种新的功能性技术在核神经学。
Primary brain tumours are usually assessed by computed tomography (CT) and magnetic resonance imaging (MRI), sometimes in conjunction with positron emission tomography (PET). We used cobalt-55 (Co-55) as a calcium (Ga) tracer to visualize decaying tumour tissue, based on the fact that Ca-influx is essential in both cell death and leukocyte activation. Net Co-55 uptake may be the result of cell decay, leukocyte infiltration, (re)perfusion and the pharmacological profile of Co-55. Three patients with primary malignant brain tumours (first presentation) were studied with CT, MRI and Go-PET after the intravenous administration of 0.5 mCi Co-55. Histopathological diagnosis was obtained by biopsy or resection. Go-PET demonstrated each of the brain tumours and showed good topographical agreement with CT and MRI. Go-PET provided additional detail as to the site and size of the necrotic core and the peri-necrotic rim of decaying tumour. The Co-55 uptake indices varied between 2.6 and 5.3. Co-55 demonstrated uptake in decaying tissue, irrespective of the integrity of the blood-brain barrier. Neither necrotic nor viable tumour tissue showed affinity for Co-55. Since Co-55 is readily applicable to both PET and single photon emission tomography (SPET), differences in the uptake mechanism and functional significance of the Co-55 tracer are discussed in relation to Tl-201 SPET. We present a (limited) pilot series of three patients to forward the claim of this new functional technique in nuclear neurology.