Humour processing in frontotemporal lobar degeneration: A behavioural and neuroanatomical analysis.
Humour processing in frontotemporal lobar degeneration: A behavioural and neuroanatomical analysis.
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DOI：
10.1016/j.cortex.2015.03.024
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Warren JD
中科院分区：
文献类型：
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作者：
Clark CN;Nicholas JM;Henley SM;Downey LE;Woollacott IO;Golden HL;Fletcher PD;Mummery CJ;Schott JM;Rohrer JD;Crutch SJ;Warren JD
幽默是一种复杂的认知和情感结构，在神经退行性疾病中是脆弱的，特别是额颞叶退化。然而，这些疾病中的幽默加工研究很少。在这里，我们评估了幽默处理的患者行为变异额颞叶痴呆（n = 22，平均年龄67岁，4名女性）和语义痴呆（n = 11，平均年龄67岁，5名女性）相对于健康人（n = 21，平均年龄66岁，11名女性），使用联合认知和神经解剖学的方法。我们创建了一个新的神经心理学测试，需要一个决定的幽默意图的非语言漫画，在其中我们操纵正交幽默内容和熟悉的描绘场景。结构神经解剖学相关的幽默检测进行了评估，使用基于体素的形态测量。在信号检测框架中评估表现，并在调整认知功能的标准测量后，两组患者在熟悉和新场景中的幽默检测准确性相对于健康的老年对照组受损（p < .001）。患者组显示出相似的总体性能特征;然而，行为变异型额颞叶痴呆组单独显示出在熟悉场景中检测幽默相对于新场景的显著优势，（p = 0.045），表明行为变异综合征可能导致对幽默的新情况进行解码的特别困难，而语义性痴呆产生了更普遍的幽默检测缺陷，其延伸到股票喜剧情境。幽默检测的准确性与分布式网络中的灰质体积相关，包括颞顶叶交界区和前上级颞叶皮质，主要是在熟悉的场景中处理幽默的左侧相关性和处理新幽默的右侧相关性。研究结果量化赤字的核心认知操作支持幽默处理额颞叶退化，并提出了一个候选人的大脑基板在皮层枢纽地区处理不协调和语义关联。幽默是一个很有前途的候选工具，可以用来评估神经退行性疾病中复杂的社会信号处理。
Humour is a complex cognitive and emotional construct that is vulnerable in neurodegenerative diseases, notably the frontotemporal lobar degenerations. However, humour processing in these diseases has been little studied. Here we assessed humour processing in patients with behavioural variant frontotemporal dementia (n = 22, mean age 67 years, four female) and semantic dementia (n = 11, mean age 67 years, five female) relative to healthy individuals (n = 21, mean age 66 years, 11 female), using a joint cognitive and neuroanatomical approach. We created a novel neuropsychological test requiring a decision about the humorous intent of nonverbal cartoons, in which we manipulated orthogonally humour content and familiarity of depicted scenarios. Structural neuroanatomical correlates of humour detection were assessed using voxel-based morphometry. Assessing performance in a signal detection framework and after adjusting for standard measures of cognitive function, both patient groups showed impaired accuracy of humour detection in familiar and novel scenarios relative to healthy older controls (p < .001). Patient groups showed similar overall performance profiles; however the behavioural variant frontotemporal dementia group alone showed a significant advantage for detection of humour in familiar relative to novel scenarios (p = .045), suggesting that the behavioural variant syndrome may lead to particular difficulty decoding novel situations for humour, while semantic dementia produces a more general deficit of humour detection that extends to stock comedic situations. Humour detection accuracy was associated with grey matter volume in a distributed network including temporo-parietal junctional and anterior superior temporal cortices, with predominantly left-sided correlates of processing humour in familiar scenarios and right-sided correlates of processing novel humour. The findings quantify deficits of core cognitive operations underpinning humour processing in frontotemporal lobar degenerations and suggest a candidate brain substrate in cortical hub regions processing incongruity and semantic associations. Humour is a promising candidate tool with which to assess complex social signal processing in neurodegenerative disease.