African Pharmacogenomics Consortium:Consolidating pharmacogenomics knowledge, capacity development and translation in Africa: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa.
African Pharmacogenomics Consortium:Consolidating pharmacogenomics knowledge, capacity development and translation in Africa: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa.
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DOI：
10.12688/aasopenres.12965.1
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Bolaji, Oluseye
中科院分区：
文献类型：
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作者：
Dandara, Collet;Masimirembwa, Collen;Bolaji, Oluseye
非洲药物基因组学联盟 (APC) 于 2018 年 9 月 6 日正式成立。本白皮书概述了其愿景和目标，以应对在非洲进行和应用药物基因组学的挑战，并确定了推进非洲大陆个体化药物使用的机会。非洲，特别是撒哈拉以南地区，面临着巨大的传染病负担，这些疾病具有多种共病，其多样性和交叉性是实现可持续发展目标（SDG）（SDG3）健康和福祉的主要挑战。与世界其他地区相比，非洲人群常用的药物导致了不同范围的药物不良反应 (ADR)。鉴于非洲人的遗传多样性，APC 的成立是为了促进药物基因组学研究及其临床实施，以确保非洲大陆安全有效地用药。患者对治疗反应方式的变化主要是由于与每种药物的处置相关的途径所涉及的酶和转运蛋白的活性差异所致。因此，药物基因组学知识有助于识别这些蛋白质的遗传变异及其功能效应。非洲需要巩固其药物基因组学专业知识和技术平台，以利用药物基因组学。
The African Pharmacogenomics Consortium (APC) was formally launched on the 6th September 2018. This white paper outlines its vision, and objectives towards addressing challenges of conducting and applying pharmacogenomics in Africa and identifies opportunities for advancement of individualized drugs use on the continent. Africa, especially south of the Sahara, is beset with a huge burden of infectious diseases with much co-morbidity whose multiplicity and intersection are major challenges in achieving the sustainable development goals (SDG), SDG3, on health and wellness. The profile of drugs commonly used in African populations lead to a different spectrum of adverse drug reactions (ADRs) when compared to other parts of the world. Coupled with the genetic diversity among Africans, the APC is established to promote pharmacogenomics research and its clinical implementation for safe and effective use of medicine in the continent. Variation in the way patients respond to treatment is mainly due to differences in activity of enzymes and transporters involved in pathways associated with each drug's disposition. Knowledge of pharmacogenomics, therefore, helps in identifying genetic variants in these proteins and their functional effects. Africa needs to consolidate its pharmacogenomics expertise and technological platforms to bring pharmacogenomics to use.