Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment
Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment
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DOI：
10.1093/cercor/bhv062
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发表时间：
2016-06-01
期刊：
影响因子：
3.7
通讯作者：
Teipel, Stefan J.
中科院分区：
文献类型：
--
作者：
Grothe, Michel J.;Heinsen, Helmut;Teipel, Stefan J.
基底前脑（BF）胆碱能核的变性与认知能力下降有关，这种效应被认为是由去神经皮层区域的神经元功能障碍介导的。基于 MRI 的 BF 萎缩测量越来越多地被用作胆碱能变性的体内替代标记，但 BF 体积减少的功能影响尚不清楚。我们使用高分辨率 MRI、氟脱氧葡萄糖-正电子发射断层扫描 (PET) 以及 132 名轻度认知障碍 (MCI) 受试者和 177 名认知正常对照受试者的神经心理学测试数据来确定 BF 萎缩、皮质代谢低下和认知缺陷之间的关联。 MCI 中的 BF 萎缩与记忆功能受损和注意力控制缺陷相关，而海马体积与记忆缺陷更具体相关。 BF 萎缩还与广泛的皮质代谢低下有关，路径分析模型表明，特定领域皮质网络中的代谢低下介导了 BF 体积和认知功能障碍之间的关联。使用 AV45-PET 评估的皮质淀粉样蛋白病理学的存在与观察到的关联没有显着相互作用。这些数据强调了多模态成像标记物在研究活体人脑结构-功能-认知关系方面的潜力，并为人类 BF 参与皮质活动和认知功能提供重要的体内证据。
Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline, and this effect is believed to be mediated by neuronal dysfunction in the denervated cortical areas. MRI-based measurements of BF atrophy are increasingly being used as in vivo surrogate markers for cholinergic degeneration, but the functional implications of reductions in BF volume are not well understood. We used high-resolution MRI, fluorodeoxyglucose-positron emission tomography (PET), and neuropsychological test data of 132 subjects with mild cognitive impairment (MCI) and 177 cognitively normal controls to determine associations between BF atrophy, cortical hypometabolism, and cognitive deficits. BF atrophy in MCI correlated with both impaired memory function and attentional control deficits, whereas hippocampus volume was more specifically associated with memory deficits. BF atrophy was also associated with widespread cortical hypometabolism, and path analytic models indicated that hypometabolism in domain-specific cortical networks mediated the association between BF volume and cognitive dysfunction. The presence of cortical amyloid pathology, as assessed using AV45-PET, did not significantly interact with the observed associations. These data underline the potential of multimodal imaging markers to study structure-function-cognition relationships in the living human brain and provide important in vivo evidence for an involvement of the human BF in cortical activity and cognitive function.