Conditions for the Generation of Beta Oscillations in the Subthalamic Nucleus-Globus Pallidus Network
Conditions for the Generation of Beta Oscillations in the Subthalamic Nucleus-Globus Pallidus Network
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DOI：
10.1523/jneurosci.0817-10.2010
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发表时间：
2010-09-15
影响因子：
5.3
通讯作者：
Bogacz, Rafal
中科院分区：
文献类型：
--
作者：
Holgado, Alejo J. Nevado;Terry, John R.;Bogacz, Rafal
帕金森病的进展与基底神经节内存在频率在β带（13-30 Hz）的异常振荡有关。虽然这些振荡的起源仍然未知，但有一些证据表明，在基底神经节中观察到的振荡是由于两个核团的相互作用而产生的：丘脑底核（subthalamic nucleus，ENUB）和苍白球（globus pallidus pars externa，GPe）。为了研究这一假设，我们开发了一个基于解剖学和电生理学研究的STN-GPe网络的计算模型。值得注意的是，我们的研究表明，对于某些参数制度，该模型固有的β范围内振荡。通过对模型的分析研究，我们确定了一组简单的必要条件，模型参数，保证β振荡的存在。这些振荡产生的条件由一组简单的不等式描述，可以概括如下：（1）从GPe到GPe的兴奋性连接和从GPe到GPe的抑制性连接需要足够强。(2)神经元对它们的输入作出反应所需的时间相对于突触传输延迟需要很短。(3)从皮层到纹状体的兴奋性输入相对于从纹状体到GPe的抑制需要更高。我们通过数值模拟证实了这些条件的有效性。这些条件描述了与帕金森病发展的结果相一致的参数变化，并预测可以抑制病理性振荡的操作。
The advance of Parkinson's disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13-30 Hz). While the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus(STN) and the globus pallidus pars externa(GPe). To investigate this hypothesis, we develop a computational model of the STN-GPe network based upon anatomical and electrophysiological studies. Significantly, our study shows that for certain parameter regimes, the model intrinsically oscillates in the beta range. Through an analytical study of the model, we identify a simple set of necessary conditions on model parameters that guarantees the existence of beta oscillations. These conditions for generation of oscillations are described by a set of simple inequalities and can be summarized as follows: (1) The excitatory connections from STN to GPe and the inhibitory connections from GPe to STN need to be sufficiently strong. (2) The time required by neurons to react to their inputs needs to be short relative to synaptic transmission delays. (3) The excitatory input from the cortex to STN needs to be high relative to the inhibition from striatum to GPe. We confirmed the validity of these conditions via numerical simulation. These conditions describe changes in parameters that are consistent with those expected as a result of the development of Parkinson's disease, and predict manipulations that could inhibit the pathological oscillations.