MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN.
MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN.
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MiR-200c 是一种 cMyc 激活的 miRNA，通过下调 PTEN 促进鼻咽癌。
DOI：
10.18632/oncotarget.14123
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发表时间：
2017-01-17
期刊：
影响因子：
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通讯作者：
Li X
中科院分区：
文献类型：
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作者：
Chen P;Guo X;Zhang L;Zhang W;Zhou Q;Tian Z;Zheng Y;Liao Q;Wang H;Li G;Huang J;Li X
c-Myc转录因子通过靶向大量蛋白质编码基因和非编码RNA调节导致细胞转化的复杂转录程序。在这项研究中，我们发现microRNA，miR-200 c，是一种新的c-Myc靶点，可促进鼻咽癌的细胞转化和转移。MiR-200 c至少部分地通过靶向和抑制肿瘤抑制基因PTEN（磷酸酶和张力蛋白同源物）来实现这种致癌作用，该基因是促进鼻咽癌中肿瘤发生的AKT激酶信号传导的关键抑制剂。因此，我们的研究将cMyc-miR-200 c-PTEN-AKT鉴定为促进鼻咽癌细胞转化的功能模块。
The c-Myc transcription factor regulates a complex transcriptional program that leads to cellular transformation by targeting a large number of protein-encoding genes and non-coding RNAs. In this study, we show that a microRNA, miR-200c, is a novel c-Myc target that promotes cellular transformation and metastasis in nasopharyngeal carcinoma. MiR-200c achieves this oncogenic effect, at least in part, by targeting and inhibiting the tumor suppressor gene PTEN (phosphatase and tensin homolog), which is a key inhibitor of the AKT kinase signaling that promotes tumorigenesis in nasopharyngeal carcinoma. Our study thus identifies cMyc-miR-200c-PTEN-AKT as a functional module that promotes cellular transformation in nasopharyngeal carcinoma.