Callosal tracts and patterns of hemispheric dominance: A combined fMRI and DTI study
Callosal tracts and patterns of hemispheric dominance: A combined fMRI and DTI study
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DOI：
10.1016/j.neuroimage.2010.09.072
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发表时间：
2011-01-15
期刊：
影响因子：
5.7
通讯作者：
Corballis, Michael C.
中科院分区：
文献类型：
--
作者：
Haeberling, Isabelle S.;Badzakova-Trajkov, Gjurgjica;Corballis, Michael C.
语言的左半球优势和空间处理的右半球优势是人类大脑的显著特征。然而，这些半球不对称的变化已经被观察到，少数表现出两个功能挤在同一个半球，甚至是典型的侧化模式的镜像逆转。在这里，我们使用扩散张量成像和功能磁成像来研究胼胝体在非典型半球优势参与者中的作用。根据基底纤维束的投射位置对胼胝体进行分割。对已识别胼胝体片段的微观结构分析表明，非典型半球语言优势与整个胼胝体的高各向异性扩散有关。这种效应在两个功能都向右拥挤的参与者中最为明显。在非典型半球优势中增强的各向异性扩散表明，在这些个体中，两个半球之间的联系更加紧密。(C) 2010爱思唯尔公司版权所有。
Left-hemispheric dominance for language and right-hemispheric dominance for spatial processing are distinctive characteristics of the human brain. However, variations of these hemispheric asymmetries have been observed, with a minority showing crowding of both functions to the same hemisphere or even a mirror reversal of the typical lateralization pattern. Here, we used diffusion tensor imaging and functional magnetic imaging to investigate the role of the corpus callosum in participants with atypical hemispheric dominance. The corpus callosum was segmented according to the projection site of the underlying fibre tracts. Analyses of the microstructure of the identified callosal segments revealed that atypical hemispheric dominance for language was associated with high anisotropic diffusion through the corpus callosum as a whole. This effect was most evident in participants with crowding of both functions to the right. The enhanced anisotropic diffusion in atypical hemispheric dominance implies that in these individuals the two hemispheres are more heavily interconnected. (C) 2010 Elsevier Inc. All rights reserved.