Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index
Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index
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DOI：
10.1007/s11745-001-0713-9
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发表时间：
2001-03-01
期刊：
影响因子：
1.9
通讯作者：
Wang, CH
中科院分区：
文献类型：
--
作者：
Huang, ZS;Chien, KL;Wang, CH
不同脂质的血液浓度和外周总白细胞计数之间的各种关系的报告，以及高胆固醇血症中独特的较低外周单核细胞计数，促使我们认为，在人类中，外周白细胞分类计数可能受到不同类型的高脂血症的不同影响。研究对象为1998年在本院参加定期健康检查的台北市居民。共入组3，282例受试者，包括1，677例血脂正常的受试者、960例未经治疗的临界高血脂受试者和645例未经治疗的高血脂受试者。通过单因素方差分析（ANOVA），我们发现不同类型的高脂血症与白细胞分类计数的显着差异。高血脂组白细胞总数及各亚型均显著高于正常血脂组。相比之下，单纯的高胆固醇血症与单核细胞计数显著降低相关，其他白细胞计数无显著差异。通过调整高脂血症的存在和程度的双因素方差分析，我们发现吸烟者的总白细胞和所有白细胞亚型的计数显着较高，体重指数（BMI）和所有白细胞，中性粒细胞，淋巴细胞和单核细胞计数之间的关系显着正趋势。多因素回归分析显示，血清甘油三酯（TC）水平与白细胞总数及除嗜酸性粒细胞外的各亚型均呈正相关。相反，血清高密度脂蛋白胆固醇与总白细胞计数、中性粒细胞、单核细胞和嗜碱性粒细胞计数呈负相关。在这些多变量回归分析中，血脂水平和嗜酸性粒细胞计数之间没有显著相关性，而吸烟始终与所有白细胞亚型（包括嗜酸性粒细胞）的显著较高计数相关。BMI与所有白细胞、中性粒细胞、淋巴细胞和单核细胞计数呈显著正相关。
Reports of diverse relationships between blood concentrations of different lipids and peripheral total leukocyte count, and a unique lower peripheral monocyte count in hypercholesterolemia, have driven us to think that in humans, peripheral differential leukocyte counts may be influenced differently by different types of hyperlipidemia. Our subjects were Taipei residents who attended a regular health check program in our hospital in 1998. A total of 3,282 subjects was enrolled, including 1,677 normolipidemic, 960 untreated borderline hyperlipidemic and 645 untreated hyperlipidemic subjects. By one-way analysis of variance (ANOVA), we found that different types of hyperlipidemia were associated with significant differences in differential leukocyte counts. In hypertriglyceridemia, the total leukocyte count and counts of all leukocyte subtypes were significantly higher than those in normolipidemia. Pure hypercholesterolemia, by contrast, was associated with a significantly lower monocyte count and no significant difference in other leukocyte counts. By two-way ANOVA adjusted for presence and degree of hyperlipidemia, we found significantly higher counts of total leukocytes and of all leukocyte subtypes in smokers, and significantly positive trends in relationships between body mass index (BMI) and counts of all leukocytes, neutrophils, lymphocytes, and monocytes. By multivariate regression analysis including all subjects, the serum triglyceride (TC) level was positively correlated with total leukocyte count and counts of all subtypes except eosinophils. On the contrary, serum high density lipoprotein-cholesterol had a negative correlation with total leukocyte count and with counts of neutrophils, monocytes, and basophils. In these multivariate regression analyses, there was no significant correlation between lipid levels and eosinophil count, whereas smoking was consistently associated with significantly higher counts of all leukocyte subtypes, including eosinophils. BMI had a significantly positive correlation with counts of all leukocytes, neutrophils, lymphocytes, and monocytes.