Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell.
Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell.
复制标题
DOI：
10.1186/1747-1028-1-32
复制
发表时间：
2006-12-18
期刊：
影响因子：
2.3
通讯作者：
Stacey DW
中科院分区：
文献类型：
--
作者：
Yang K;Hitomi M;Stacey DW
我们提出的证据表明，细胞周期中细胞周期蛋白D1水平的变化是持续增殖所必需的。细胞周期蛋白D1在G1期必须高水平才能启动DNA合成，但在S期必须被抑制到低水平才能有效地合成DNA。这种在S期的抑制明显地受细胞周期位置的单独调节，并在每个细胞周期中自动发生。如果细胞要继续增殖，细胞周期蛋白D1的水平必须在G2期再次被诱导。这种诱导依赖于增殖信号分子的活性，并确保细胞外环境继续有利于生长。我们认为，在每个S阶段对细胞周期蛋白D1水平的抑制确保了随后在G2阶段的诱导，以及由此产生的对持续增殖的承诺，与细胞生长环境密切相关。
We present evidence that variations in cyclin D1 levels through the cell cycle are essential for continuing proliferation. Cyclin D1 levels must be high during G1 phase for a cell to initiate DNA synthesis, but then must be suppressed to low levels during S phase to allow for efficient DNA synthesis. This suppression during S phase is apparently regulated by cell cycle position alone and occurs automatically during each cell cycle. If the cell is to continue proliferating, cyclin D1 levels must be induced once again during G2 phase. This induction depends upon the activity of proliferative signaling molecules, and ensures that the extracellular environment continues to be conducive for growth. We propose that the suppression of cyclin D1 levels during each S phase ensures that the subsequent induction during G2 phase, and the resulting commitment to continuing proliferation, is closely linked to the cellular growth environment.
登录
查看更多内容
影响因子：
10.5
作者：
Diehl, JA;Zindy, F;Sherr, CJ
通讯作者：
Sherr, CJ
影响因子：
5.3
作者：
Papadopoulou, D;Bianchi, MW;Bourouis, M
通讯作者：
Bourouis, M
影响因子：
8
作者：
Guo, Y;Harwalkar, J;Hitomi, M
通讯作者：
Hitomi, M
影响因子：
3.7
作者：
Fukami-Kobayashi, J;Mitsui, Y
通讯作者：
Mitsui, Y
影响因子：
5.3
作者：
Aktas, H;Cai, H;Cooper, GM
通讯作者：
Cooper, GM