Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium
Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium
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DOI：
10.1080/1354750032000158420
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发表时间：
2003-11-01
期刊：
影响因子：
2.6
通讯作者：
Bernard, A
中科院分区：
文献类型：
--
作者：
Fierens, S;Mairesse, H;Bernard, A
二恶英和多氯联苯是广泛分布于食物链中的持久性有机污染物，是人类接触的主要来源。在背景接触水平下，它们对人类健康的影响仍然知之甚少。最近的流行病学证据表明，这些污染物与糖尿病之间可能存在关联。我们在这里报告的结果为基础的人口研究在比利时257（142名妇女和115名男子）环境暴露的主题，包括10例子宫内膜异位症和9例糖尿病。十七种2，3，7，8-多氯二苯并二恶英/二苯并呋喃（多氯二苯并对二恶英/多氯二苯并呋喃或二恶英），四种共面多氯联苯（国际纯粹与应用化学联合会[IUPAC]第77、81、126和169号）和12个PCB标记（IUPAC第3、8、28、52、101、118、138、153、180、194、206和209号）对空腹血液样本的血清脂肪进行定量，以估计这些污染物的身体负担。虽然没有发现子宫内膜异位症妇女和他们的对照组之间的差异，糖尿病患者显着增加二恶英，共面PCB和12 PCB标记物的血清水平。调整年龄和其他协变量后，血清总毒性当量活性（PCDD/Fs和共面PCB的总和）和12个PCB标记物浓度在糖尿病患者分别为62%（p=0.0005）和39%（p=0.0067），高于对照组。在二恶英（比值比5.1，95%置信区间[CI] 1.18-21.7）、共面多氯联苯（比值比13.3，95% CI 3.31-53.2）或12种多氯联苯标记物（比值比7.6，95% CI 1.58-36.3）校正浓度的前十分位中，糖尿病风险显著增加。这些发现证明需要进一步研究，以评估糖尿病与环境中多氯污染物接触之间的关联的重要性。
Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background exposure levels are still poorly understood. Recent epidemiological evidence suggests a possible association between these pollutants and diabetes. We report here the results of a population-based study in Belgium on 257 (142 women and 115 men) environmentally exposed subjects, including 10 cases of endometriosis and nine cases of diabetes. Seventeen 2,3,7,8-polychlorinated dibenzodioxins/dibenzofurans (PCDD/Fs or dioxins), four coplanar PCBs (International Union of Pure and Applied Chemistry [IUPAC] nos 77, 81, 126 and 169) and 12 PCB markers ( IUPAC nos 3, 8, 28, 52, 101, 118, 138, 153, 180, 194, 206 and 209) were quantified in serum fat from fasting blood samples in order to estimate the body burden of these pollutants. Whilst no difference was found between women with endometriosis and their controls, diabetic patients had significantly increased serum levels of dioxins, coplanar PCBs and the 12 PCB markers. After adjustment for age and other covariates, serum total toxic equivalent activity (sum of PCDD/Fs and coplanar PCBs) and 12 PCB marker concentrations in diabetics were 62% (p=0.0005) and 39% (p=0.0067) higher, respectively, than in controls. The risk of diabetes was significantly increased in subjects in the top decile for adjusted concentrations of dioxins (odds ratio 5.1, 95% confidence interval [CI] 1.18-21.7), coplanar PCBs (odds ratio 13.3, 95% CI 3.31-53.2) or 12 PCB markers (odds ratio 7.6, 95% CI 1.58-36.3). These findings warrant further studies to assess the significance of the associations between diabetes and environmental exposure to polychlorinated pollutants.