Lipoprotein secretion and triglyceride stores in the heart
Lipoprotein secretion and triglyceride stores in the heart
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DOI：
10.1074/jbc.m106839200
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发表时间：
2001-10-19
影响因子：
4.8
通讯作者：
Young, SG
中科院分区：
文献类型：
--
作者：
Björkegren, J;Véniant, M;Young, SG
载脂蛋白B和微粒体甘油三酯转移蛋白的基因在小鼠和人心脏组织中表达。为什么心脏会表达这些“脂蛋白组装”基因还不清楚。在这里，我们证明了跳动的小鼠心脏实际上分泌球形脂蛋白。此外，增加的心脏产生的脂蛋白（例如，在表达人载脂蛋白B转基因的小鼠中）与心脏甘油三酯分泌增加和心脏内甘油三酯储存减少有关。增加心脏产生的脂蛋白也减少了甘油三酯的病理积累，发生在缺乏长链酰基辅酶A脱氢酶的小鼠心脏。相反，阻断心脏脂蛋白分泌（例如，在心脏特异性微粒体甘油三酯转移蛋白敲除小鼠中）增加心脏甘油三酯储存。因此，心脏脂蛋白分泌有助于调节心脏甘油三酯储存，并可保护心脏免受多余脂质的不利影响。
The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in mouse and human heart tissue. Why the heart would express these "lipoprotein assembly" genes has been unclear. Here we demonstrate that the beating mouse heart actually secretes spherical lipoproteins. Moreover, increased cardiac production of lipoproteins (e.g., in mice that express a human apolipoprotein B transgene) was associated with increased triglyceride secretion from the heart and decreased stores of triglycerides within the heart. Increased cardiac production of lipoproteins also reduced the pathological accumulation of triglycerides that occurs in the hearts of mice lacking long-chain acyl coenzyme A dehydrogenase. In contrast, blocking heart lipoprotein secretion (e.g., in heart-specific microsomal triglyceride transfer protein knockout mice) increased cardiac triglyceride stores. Thus, heart lipoprotein secretion helps regulate cardiac triglyceride stores and may protect the heart from the detrimental effects of surplus lipids.