Perlecan - a multifunctional extracellular proteoglycan scaffold
Perlecan - a multifunctional extracellular proteoglycan scaffold
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DOI：
10.1093/glycob/cwm043
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发表时间：
2007-09-01
期刊：
影响因子：
4.3
通讯作者：
Carson, Daniel D.
中科院分区：
文献类型：
--
作者：
Farach-Carson, Mary C.;Carson, Daniel D.
串珠素是细胞外基质的大的多结构域硫酸乙酰肝素蛋白聚糖。这种蛋白多糖的表达在胚胎着床和胎盘形成过程中动态变化。串珠素由胚胎的各种细胞表达，包括滋养外胚层和滋养层以及母体隔室，包括子宫上皮和内皮下面的基底层，并且最动态地在发育中的蜕膜中表达。串珠素支持多种生物学功能，包括细胞粘附、生长因子结合和细胞凋亡的调节。此外，在其他系统中的研究表明，串珠素的表达和活性可以在许多水平上控制，包括转录，选择性剪接和细胞外蛋白水解。这篇综述将讨论在胚胎着床和胎盘形成过程中串珠素表达的变化。此外，我们提出了一个模型，其中串珠素代表细胞外支架蛋白，支持复杂的，不同的功能，在其全长形式或较小的形式产生的mRNA剪接，细胞外蛋白水解，或糖苷酶作用。
Perlecan is a large multidomain heparan sulfate proteoglycan of the extracellular matrix. Expression of this proteoglycan changes dynamically during embryo implantation and placentation. Perlecan is expressed by various cells of the embryo including trophectoderm and trophoblast as well as the maternal compartment, including basal lamina underlying uterine epithelia and endothelia and, most dynamically, in developing decidua. Perlecan supports various biological functions, including cell adhesion, growth factor binding, and modulation of apoptosis. Moreover, studies in other systems demonstrate that perlecan expression and activity can be controlled at many levels, including transcription, alternative splicing, and extracellular proteolysis. This review will discuss changes in perlecan expression that occur during embryo implantation and placentation. Furthermore, we propose a model in which perlecan represents an extracellular scaffold protein that supports complex, distinct functions in its full-length form or smaller forms generated by alternative mRNA splicing, extracellular proteolysis, or glycosidase action.