Lectin binding and the carbohydrate moieties present on Newcastle disease virus strains.
Lectin binding and the carbohydrate moieties present on Newcastle disease virus strains.
复制标题
新城疫病毒株上存在的凝集素结合和碳水化合物部分。
DOI：
10.2307/1590538
复制
发表时间：
1986
期刊：
影响因子：
1.4
通讯作者：
R. Hanson
中科院分区：
文献类型：
--
作者：
B. Mcmillan;S. Rehmani;R. Hanson
为确定与血凝相关的碳水化合物部分，并确定病毒包膜上存在的碳水化合物与毒力之间是否存在任何关联，开发了14株纽卡斯尔病病毒的凝集素结合谱。所有纽卡斯尔病病毒株均与刀豆蛋白A结合。其他凝集素结合的病毒差异，但没有模式的结合，可以与病毒的毒力。小透镜凝集素与病毒的结合与病毒从鸡红细胞上的洗脱率有关。从鸡红细胞中快速洗脱的菌株不与小透镜凝集素结合。糖α-D-N-乙酰葡萄糖胺抑制透镜culinaris凝集素的吸附的菌株是“慢洗脱剂”从鸡红细胞。
Lectin-binding profiles were developed for 14 strains of Newcastle disease virus in order to determine the carbohydrate moieties associated with hemagglutination and to establish whether there are any associations between the carbohydrates present on the virus envelope and virulence. All strains of Newcastle disease virus were bound by concanavalin A. Other lectins bound the viruses differentially, but there was no pattern of binding that could be associated with viral virulence. The binding of virus by Lens culinaris lectin was associated with the elution rate of the virus from chicken erythrocytes. Strains that elute rapidly from chicken erythrocytes were not bound by Lens culinaris lectin. The sugar alpha-D-N-acetylglucosamine inhibited the adsorption of Lens culinaris lectin to the strains that were "slow eluters" from chicken erythrocytes.