Relation between myocardial oxygen consumption and myocardial blood volume: A study using myocardial contrast echocardiography
Relation between myocardial oxygen consumption and myocardial blood volume: A study using myocardial contrast echocardiography
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DOI：
10.1067/mje.2002.121275
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发表时间：
2002-09-01
影响因子：
6.5
通讯作者：
Kaul, S
中科院分区：
文献类型：
--
作者：
Le, DE;Bin, JP;Kaul, S
心肌血容量（MBV）是指存在于心肌血管中的血容量，其中90%位于毛细血管中。MBV可以通过心肌超声造影（MCE）在体内测量。研究表明，当冠状动脉血流量（CBF）的增加与心肌耗氧量（MVO2）的增加无关时，MBV不会增加。我们假设当CBF的增加与MVO2的增加相关时，MBV会增加。18只犬行房室结消融，双室起搏。在第1组（n=9）中，心率以随机顺序从50到150 bpm（-1）递增20 bpm（-1）。第二组（n=9）保持恒定心率，分别以5、10、20、30、40杯/kg(-1)/min（-1）的剂量输注多巴酚丁胺。在每次干预期间，测量血流动力学参数和MVO2，并进行MCE。MVO2增加(P
Myocardial blood volume (MBV) is the volume of blood residing in myocardial vessels, 90% of which is in capillaries. MBV can be measured in vivo using myocardial contrast echocardiography (MCE). it has been shown that when increases in coronary blood flow (CBF) are not associated with increase in myocardial oxygen consumption (MVO2), MBV does not increase. We hypothesized that MBV would increase when increases in CBF are associated with an increase in MVO2. The atrioventricular node was ablated in 18 dogs and dual-chamber pacing was instituted. In group 1 dogs (n=9), heart rate was altered from 50 to 150 bpm(-1) in increments of 20 bpm(-1) in random order. in group 2 dogs (n=9), heart rate was kept constant, and dobutamine was infused at doses of 5, 10, 20, 30, and 40 mug/kg(-1)/min(-1). During each intervention, hemodynamic parameters and MVO2 were measured, and MCE was performed. MVO2 increased more (P