Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
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DOI：
10.1152/physiolgenomics.00197.2003
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发表时间：
2004-12-15
影响因子：
4.6
通讯作者：
O'Donnell, CP
中科院分区：
文献类型：
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作者：
Campen, MJ;Tagaito, Y;O'Donnell, CP
遗传变异对低氧和高碳酸血症心血管反应的影响还不清楚。因此，我们确定了急性变化的全身动脉血压（PSA）和心率（HR）在七种常用的近交系小鼠暴露于急性期的缺氧（10%O-2），高碳酸血症（5%CO2），和缺氧/高碳酸血症（10%O-2 + 5%CO2）在清醒状态。高碳酸血症诱导了各品系之间基本均匀的反应，PSA维持在基线或略高于基线，HR表现出典型的压力感受器介导的心动过缓。与此相反，暴露于缺氧引起显着的异质性之间的应变心血管反应。缺氧期间PSA的变化范围从FVB/J品系中维持正常血压到DBA/2 J品系中类似于30 mmHg的深度低血压。HR反应是高度可变的菌株在缺氧期间，除了DBA/2 J菌株表现出显着的缓慢性心律失常和随之而来的低血压，HR反应是无关的PSA的变化。PSA对低氧/高碳酸血症的反应表现为高碳酸血症的高血压和低氧的低血压的平衡。在FVB/J品系中，联合低氧/高碳酸血症产生的高血压反应大于单独的高碳酸血症。这些结果表明，遗传背景影响心血管反应缺氧，但不高碳酸血症。
The impact of genetic variation on cardiovascular responses to hypoxia and hypercapnia is not well understood. Therefore, we determined the acute changes in systemic arterial blood pressure (PSA) and heart rate (HR) in seven strains of commonly used inbred mice exposed to acute periods of hypoxia (10% O-2), hypercapnia (5% CO2), and hypoxia/hypercapnia (10% O-2 + 5% CO2) during wakefulness. Hypercapnia induced an essentially homogeneous response across strains, with PSA maintained at or slightly above baseline and with HR exhibiting a typical baroreceptor-mediated bradycardia. In contrast, exposure to hypoxia elicited a marked heterogeneity in cardiovascular responses between strains. The change in PSA during hypoxia ranged from maintenance of normotension in the FVB/J strain to profound hypotension of similar to 30 mmHg in the DBA/2J strain. HR responses were highly variable between strains during hypoxia, and with the exception of the DBA/2J strain that exhibited significant bradyarrhythmias and consequent hypotension, the HR responses were unrelated to changes in PSA. The PSA response to combined hypoxia/hypercapnia represented a balance of the hypertension of hypercapnia and the hypotension of hypoxia in six of the seven strains. In the FVB/J strain, combined hypoxia/ hypercapnia produced a hypertensive response that was greater than that of hypercapnia alone. These results suggest that genetic background affects the cardiovascular response to hypoxia, but not hypercapnia.