Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)
Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)
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DOI：
10.3390/nu11030620
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发表时间：
2019-03-14
期刊：
影响因子：
5.9
通讯作者：
Kiens, Bente
中科院分区：
文献类型：
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作者：
Hansen, Solvejg L.;Lorentzen, Jakob;Kiens, Bente
脑源性神经营养因子（BDNF）是运动和营养诱导的神经可塑性的中介。在脑瘫（CP）儿童中，神经肌肉缺陷和活动障碍对他们的身体活动水平和营养状况有负面影响，但这些儿童是否有BDNF浓度降低尚不清楚。因此,本研究的目的是探讨等离子体BDNF浓度,营养状况,和身体活动水平轻微到严重CP患儿血液取样,膳食登记,并完成问卷对儿童有轻度CP(粗大运动功能分类系统(GMFCS) i ii, n = 31日10.6 + / - 0.6岁),严重的CP (GMFCS IV-V, n = 14日10.9 + / - 1.1岁)和典型发达(TD)儿童(n = 22日10.9 + / - 0.6岁)。重度CP患儿血浆BDNF浓度较TD患儿低40% （p < 0.05）。此外，重度CP患儿的每日体力活动水平低于TD患儿（p < 0.01），每日能量、n-3脂肪酸和膳食纤维摄入量仅与TD患儿相似50% （p < 0.001）。重度CP患儿血浆BDNF浓度降低，这可能对优化神经生长和可塑性具有重要意义。这与低体力活动水平和能量、n-3脂肪酸和膳食纤维的次优摄入一起观察到。
Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I-II, n = 31, age 10.6 +/- 0.6 years), severe CP (GMFCS IV-V, n = 14, age 10.9 +/- 1.1 years) and typically developed (TD) children (n = 22, age 10.9 +/- 0.6 years). Children with severe CP had similar to 40% lower plasma BDNF concentration than TD children (p < 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p < 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only similar to 50% of TD (p > 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.