Mode of cell proliferation in the developing mouse neocortex.
Mode of cell proliferation in the developing mouse neocortex.
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发育中的小鼠新皮质中的细胞增殖模式。
DOI：
10.1073/pnas.91.1.375
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发表时间：
1994
影响因子：
11.1
通讯作者：
CavinessJr,VS
中科院分区：
文献类型：
--
作者：
Takahashi,T;Nowakowski,RS;CavinessJr,VS
发育中的脑壁中有两个增殖群体：假复层心室上皮（PVE）和次级增殖群体（SPP）。本实验在小鼠胚胎第14天（E14）提供了继续增殖（增殖、P级分或P）的子细胞比例和离开细胞周期（静止、Q级分或Q; Q = 1 - P）的子细胞比例的直接测量值。PVE的P值范围为0.62-0.66，这将提供相对较低的神经元输出速率和适于E14的增殖群体的扩增。SPP的P值甚至更高（0.73-1.0），将使该群体迅速扩增，为脑组织发生后期出现的高胶质细胞输出做准备。
There are two proliferative populations in the developing cerebral wall: the pseudostratified ventricular epithelium (PVE) and the secondary proliferative population (SPP). The present experiments provide on embryonic day 14 (E14) in the mouse direct measures of the values for the proportions of daughter cells that continue to proliferate (proliferative, P fraction, or P) and for those that leave the cell cycle (quiescent, Q fraction, or Q; Q = 1 - P) for both of these populations. The range of values of P for the PVE, 0.62-0.66, would provide for the relatively low rate of neuronal output and for an expansion of the proliferative population appropriate for E14. The even higher values of P for the SPP, 0.73-1.0, would expand this population rapidly in preparation for the high glial cell output to occur later in cerebral histogenesis.