Expression of carcinoembryonic antigen cell adhesion molecule 6 oncoprotein in atypical ductal hyperplastic tissues is associated with the development of invasive breast cancer
Expression of carcinoembryonic antigen cell adhesion molecule 6 oncoprotein in atypical ductal hyperplastic tissues is associated with the development of invasive breast cancer
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DOI：
10.1158/1078-0432.ccr-05-2286
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发表时间：
2006-08-01
影响因子：
11.5
通讯作者：
Bonney, George
中科院分区：
文献类型：
--
作者：
Poola, Indira;Shokrani, Babok;Bonney, George
背景：流行病学研究证实，既往有非典型导管增生性病变(ADH)的女性患浸润性乳腺癌(IBC)的风险增加5倍。然而，目前还没有办法从最有可能患癌症的女性中识别出ADH的一个亚类。本研究旨在探讨癌胚抗原细胞黏附分子6(CEACAM6)在ADH组织中的高表达是否与IBC的发生发展有关。对照组为无IBC病史且确诊后5年内未发生肿瘤的ADH患者(n=44)。试验组为ADH患者，这些患者同时或在确诊后发展为癌症(ADHC；n=44)。结果：44例无癌病史的ADH对照组织中，有9例CEACAM6阳性。44例ADHC组织中40例阳性。结论：CEACAM6在ADH皮损中的表达与乳腺癌细胞的发生发展密切相关，可单独或与其他标志物(S)联合应用，作为诊断ADH皮损发生的标志物。它也可能成为预防IBC的潜在分子治疗靶点。
Background: Epidemiologic studies have established that women with prior atypical ductal hyperplastic (ADH) lesions have a 5-fold increased risk of developing invasive breast cancer (IBC). However, there is currently no means of identifying a subclass of ADH from women who will most likely develop cancer. The purpose of this study is to investigate whether elevated expression of carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in ADH tissues is associated with the development of IBC.Methods: A retrospective study was conducted with archival ADH tissues and clinical information on the development/nondevelopment of IBC. The control group was ADH from patients who had no prior history of IBC and did not develop cancer within 5 years after the diagnosis of ADH (n = 44). The test group was ADH from patients who either developed cancer concurrently or subsequently after diagnosis (ADHC; n = 44). The expression of CEACAM6 was studied by immunohistochemistry and the results were statistically analyzed for significant association to develop cancer (P value), specificity, sensitivity, positive predictive value, and negative predictive value.Results: Of the 44 control ADH tissues from patients with no history of cancer, 9 were positive for CEACAM6. Among the ADHC tissues, 40 of 44 samples were positive. Statistical analysis of CEACAM6 expression data showed a significant association between its expression and cancer development, high sensitivity, specificity, positive predictive value, and negative predictive value.Conclusions: The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions. It could also be a potential molecular therapeutic target for preventing IBC.