Anaplastic large cell lymphoma: clinicopathological and immunohistochemical study of 20 cases classified according to the 2016 revision of the World Health Organization classification of lymphoid neoplasms
Anaplastic large cell lymphoma: clinicopathological and immunohistochemical study of 20 cases classified according to the 2016 revision of the World Health Organization classification of lymphoid neoplasms
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DOI：
10.24875/j.gamo.m17000075
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发表时间：
2017-07-01
影响因子：
0.1
通讯作者：
Ortiz-Hidalgo, Carlos
中科院分区：
文献类型：
--
作者：
Brisa Sevilla-Lizcano, Diana;Ortiz-Hidalgo, Carlos
间变性大细胞淋巴瘤（ALCL）是一种由 CD30 阳性肿瘤细胞组成的非霍奇金淋巴瘤。 2016 年修订的 WHO 淋巴肿瘤分类包括间变性淋巴瘤激酶 (ALK) 阳性、ALK 阴性和乳房植入物相关 ALCL。 ALCL 阳性病例和阴性病例具有不同的临床和预后特征。 ALK-1阳性病例大多发生在生命的前三十岁，而ALK-1阴性患者年龄较大。 ALCL 表现出非常广泛的细胞学表现，包括普通型、淋巴组织细胞型、小细胞型、霍奇金样型和复合型。根据定义，ALCL 在细胞膜和高尔基体区域显示出强烈的 CD30 染色，大多数上皮膜抗原呈阳性，表达一种或多种 T 细胞或自然杀伤抗原，并且 Epstein-Barr 病毒始终呈阴性。我们提出了在同一机构研究的 20 例 ALCL 病例的临床病理学和免疫组织化学分析，并根据 2016 年修订的淋巴肿瘤进行分类。 9 例为 ALK-1 阳性，10 例为 ALK-1 阴性，1 例为乳房植入物相关 ALCL ALK-1 阴性。
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma composed of CD30-positive neoplastic cells. The 2016 revision of the WHO classification of lymphoid neoplasms includes anaplastic lymphoma kinase (ALK) positive, ALK negative and breast implant associated ALCL. ALCL have distinct clinical and prognostic features between positive and negative cases. ALK-1 positive cases mostly occur in the first three decades of life while patients with ALK-1 negative are older. ALCL exhibit a very broad range of cytology appearances that include common pattern, lymphohistiocytic pattern, small-cell pattern, Hodgkin-like pattern and composite pattern. By definition, ALCL show strong CD30 staining on the cell membrane and in the Golgi region and the majority are epithelial membrane antigen positive, express one or more T-cell or Natural Killer antigens and are constantly negative for Epstein-Barr virus. We present the clinicopathologic and immunohistochemical analysis of 20 cases of ALCL studied at a single institution, classified according to the 2016 revision of lymphoid neoplasms. Nine cases were ALK-1 positive, ten ALK-1 negative, and one case as a breast implant associated ALCL ALK-1 negative.