Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats
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DOI：
10.1089/jmf.2014.3346
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发表时间：
2015-08-01
影响因子：
2.4
通讯作者：
Kim, Hyun Jee
中科院分区：
文献类型：
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作者：
Kim, Hyun Jee
本研究的目的是探讨小檗碱是否可以改善大鼠坐骨神经慢性压迫性损伤（CCI）引起的异常性疼痛。在诱导CCI后，观察到从冷板试验（冷异常性疼痛）的提爪次数显著增加和在von Frey毛发刺激试验（机械异常性疼痛）中缩爪阈值降低。然而，这些寒冷和机械异常性疼痛显着缓解小檗碱管理中的剂量依赖性方式。坐骨神经髓过氧化物酶和丙二醛的活动也减弱小檗碱管理。连续注射7天未诱导耐受性的产生。小檗碱20 mg/kg的抗痛觉超敏作用与阿米替林10 mg/kg相当。本研究表明，小檗碱可以减轻CCI（一种神经病理性疼痛模型）诱导的异常性疼痛，这表明小檗碱的抗炎和抗氧化特性有助于CCI模型中的抗异常性疼痛作用。
The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. After inducement of CCI, significant increases in the number of paw lifts from a cold plate test (cold allodynia) and decreased paw withdrawal threshold in the von Frey hair stimulation test (mechanical allodynia) were observed. However, these cold and mechanical allodynia were markedly alleviated by berberine administration in a dose-dependent manner. Sciatic nerve myeloperoxidase and malondialdehyde activities were also attenuated by berberine administration. Continuous injection for 7 days induced no development of tolerance. The antiallodynic effect of 20mg/kg berberine was comparable to that of amitriptyline 10mg/kg. This study demonstrated that berberine could mitigate allodynia induced by CCI, a neuropathic pain model, and it suggested that the anti-inflammatory and antioxidative properties of berberine contributed to the antiallodynic effect in the CCI model.