Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail.
Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail.
复制标题
细胞骨架蛋白 radixin 通过与其细胞质尾部结合来激活整合素 alpha(M)beta(2)。
DOI：
10.1016/j.febslet.2007.02.013
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发表时间：
2007
期刊：
影响因子：
3.5
通讯作者：
Zhang,Li
中科院分区：
文献类型：
--
作者：
Tang,Pingtao;Cao,Chunzhang;Xu,Min;Zhang,Li
Talin binding of integrins, via its band 4.1, ezrin, radixin, and moesin (FERM)-homologous domain, directly activates the integrin receptor. However, it is not known whether other FERM-containing proteins also possess such an integrin activating capability. We report here that radixin, one of the original FERM-domain proteins, binds to the membrane-proximal region of the integrin β2but not αMcytoplasmic tail. Importantly, we show that radixin binding significantly enhances the adhesive activity of integrin αMβ2. Given the distinct biological activities of radixin and talin, radixin may represent a novel talin-independent pathway for integrin activation under specific settings.
